CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2020, Vol. 38 ›› Issue (3): 271-278.doi: 10.12140/j.issn.1000-7423.2020.03.003
• ORIGINAL ARTICLES • Previous Articles Next Articles
LI Zhi-dan1, ZHANG Wei2, WANG Xiao-ling1, XU Bin1, HU Wei1,2,*()
Received:
2019-12-20
Online:
2020-06-30
Published:
2020-07-07
Contact:
Wei HU
E-mail:huw@fudan.edu.cn
Supported by:
CLC Number:
LI Zhi-dan, ZHANG Wei, WANG Xiao-ling, XU Bin, HU Wei. Effects of Schistosoma japonicum infection on OVA-induced allergic airway inflammation in mice[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(3): 271-278.
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URL: https://www.jsczz.cn/EN/10.12140/j.issn.1000-7423.2020.03.003
Fig. 1
Effects of S. japonicum infection on serum levels of IgE and OVA-specific IgE in mice with allergic airway inflammation induced by OVA Ⅰ-Ⅲ: IgE level in serum on days 35, 42 and 49 after schistosome infection; Ⅳ-Ⅵ: OVA-specific IgE level in serum on day 35, 42 and 49 after schistosome infection. A, B, C, D: Healthy control group, infection group, OVA group and infection + OVA group. a: P < 0.05; b: P < 0.01
Fig. 2
Effects of S. japonicum infection on histopathological changes of lung tissues in mice with allergic airway inflammation induced by OVA (× 200) Ⅰ: HE staining; Ⅱ: PAS staining. A, E: Healthy control group, with intact structure of the pulmonary alveoli and with no inflammatory cell infiltration; B, F: Infection group, with diffused inflammatory cell infiltration in the lung tissue; C, G: OVA group, with dramatic inflammatory cell infiltration and aggregation around the pulmonary vasculature and bronchus (C) and hyperplasia of bronchial epithelial cells (G); D, H: infection + OVA group, with inflammatory cell infiltration and aggregation around the pulmonary vasculature and bronchus (D) and hyperplasia of bronchial epithelial cells (H)
Fig. 3
Changes of lung inflammation and hyperplasia score after S. japonicum infection in mice with allergic airway inflammation induced by OVA Ⅰ: Analysis of inflammation score; Ⅱ: Analysis of hyperplasia score of bronchial epithelial cells. A: Healthy control group; B: Infection group; C: OVA group; D: Infection+OVA group. a: P < 0.05; b: P < 0.01
Fig. 4
The proportions of Treg cells in lung and spleen tissues after S. japonicum infection in mice with allergic airway inflammation induced by OVA A: Healthy control group; B: Infection group; C: OVA group; D: Infection+OVA group. Ⅰ, Ⅲ: Flow cytometry images of Treg cell proportions in lung tissues; Ⅱ, Ⅳ: Flow cytometry images of Treg cell proportions in spleen tissues. a: P < 0.05; b: P < 0.01
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