CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2020, Vol. 38 ›› Issue (3): 263-270.doi: 10.12140/j.issn.1000-7423.2020.03.002
• ORIGINAL ARTICLES • Previous Articles Next Articles
WANG Wei1, ZHAO Cheng-si1, MIAO Ting-ting1, ZHOU Chun-lei2, ZHANG Cheng-cheng1, QIN Min1, SHAO Tian-ye1, WANG Yong1,*()
Received:
2020-05-18
Online:
2020-06-30
Published:
2020-07-07
Contact:
Yong WANG
E-mail:yongwsh@njmu.edu.cn
Supported by:
CLC Number:
WANG Wei, ZHAO Cheng-si, MIAO Ting-ting, ZHOU Chun-lei, ZHANG Cheng-cheng, QIN Min, SHAO Tian-ye, WANG Yong. Praziquantel inhibits splenic macrophage proliferation and inflammatory reaction in mice infected with Schistosoma japonicum[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(3): 263-270.
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URL: https://www.jsczz.cn/EN/10.12140/j.issn.1000-7423.2020.03.002
Fig. 1
Alterations of splenic appearance and histopathology of Schistosoma japonicum-infected mice after praziquantel treatment A-D: Visual inspection of mouse spleen in healthy control group, uninfected plus praziquantel-treatment group, infected group and infected plus praziquantel-treatment group; E-H: Mouse splenic tissue (HE staining, × 100). E, F: In the healthy control group and the uninfected plus praziquantel-treatment group, the parenchyma of the spleens were clearly structured, the splenic cells were arranged regularly, and there was no pathological damage to the spleens; G: In the infected group, the histological structure of the spleen was disordered, the splenic sinus was partially congested, and the cells were arranged irregularly; H: In the infected plus praziquantel-treatment group, the parenchymal splenic structure was restored, and the splenic cells were regularly distributed
Fig. 2
Effects of praziquantel treatment on proportion and number of Ly-6C+ macrophages in mouse spleen Ⅰ: Proportion of total splenic macrophages in mice detected by flow cytometry; Ⅱ: Proportion of Ly-6C+ macrophages in the spleen detected by flow cytometry. A: Healthy control group; B: Uninfected plus praziquantel-treatment group; C: Infected group; D: Infected plus praziquantel-treatment group
Fig. 3
Effect of praziquantel treatment on the recruitment and proliferation of Ly-6C+ macrophages in mouse spleen A: GFP-positive macrophages in the spleen detected by flow cytometry; B: Ki-67 expression in Ly-6C+ macrophages in the spleen assessed by flow cytometry; C: Proportion of Ly-6C+ macrophages in the splenic adherent cells detected by flow cytometry
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