Research progress on the mechanism of Clonorchis sinensis miRNAs in the initiation and progression of cholangiocarcinoma

doi:10.12140/j.issn.1000-7423.2025.02.018

Abstract

Abstract:

Clonorchis sinensis is a food-borne parasite. T he adult worms parasitize in the hepatic bile ducts of the host, which could cause pathological changes and induce cholangiocarcinoma. The International Agency for Research on Cancer of the World Health Organization classified C. sinensis as a Class Ⅰ carcinogen in 2009. As a class of endogenous non-coding RNA, micro RNA (miRNA) has a variety of important regulatory roles in cells. MiRNAs secreted by C. sinensis play a relatively important role in the initiation and progression of cholangiocarcinoma. This review summarized the roles of C. sinensis-derived miRNAs in cholangiocarcinoma, aiming to provide novel strategies for preventing and treating cholangiocarcinoma induced by C. sinensis infection.

Key words: Clonorchis sinensis, miRNA, Cholangiocarcinoma, Immune regulation

CLC Number:

R383.22

WU Aoxun, ZHONG Zifeng, XU Anyuan, PAN Xiaowen, YI Xueqing, WU Yinjuan, LI Xuerong. Research progress on the mechanism of Clonorchis sinensis miRNAs in the initiation and progression of cholangiocarcinoma[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(2): 269-273.

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