Research progress on the cellular signal pathways associated in alveolar echinococcosis

doi:10.12140/j.issn.1000-7423.2023.02.016

Abstract

Abstract:

Alveolar echinococcosis (AE) is a highly harmful zoonotic parasitic disease, which is prevalent in the high latitudes of the northern hemisphere. AE usually occurs in liver tissue and Echinococcus grows infiltratively in patients. It can cause serious damage to the morphology and physiological function of the involved organs. In this process, the cellular signaling pathway is closely related to the course of AE. Cell signaling pathways, such as the mitogen-activated protein kinases (MAPK) pathway, insulin (Ins) pathway, programmed cell death protein 1 (PD-1) pathway and transforming growth factor β (TGF-β) pathway, are closely related to proliferation of Echinococcus, body immune response and differentiation of immune cells. This article has reviewed the role of related cellular signaling pathways in the immune regulation of alveolar echinococcosis and host in the process of AE infection.

Key words: Alveolar echinococcosis, Cellular signaling pathway, Immune regulation

CLC Number:

R532.32

MA Hui, CHONG Shigui, CHEN Gen, ZHANG Linghui, QIN Junmei, ZHAO Yumin. Research progress on the cellular signal pathways associated in alveolar echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(2): 223-227.

Figures/Tables 1

References 48

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