Research progress of immune regulation protein B7 family on immune regulation during Schistosoma japonicum infection

doi:10.12140/j.issn.1000-7423.2022.06.013

Abstract

Abstract:

Schistosomiasis japonica is one of the most serious zoonotic diseases in the world. After schistosome infection, Th1 cells secrete interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and CD8⁺ T cells exert cellular immunity at the early stage. Th2 cells secrete a large amount of interleukin-4 (IL-4), interleukin-13 (IL-13) and interleukin-12 (IL-12), and the function of Th1 cells is inhibited in the later stage, thus prompting the host to produce an adaptive immune response dominated by humoral immunity. The B7 family is a secondary signal of T cell activation and plays a crucial role in regulating T cell immune responses. Further studies demonstrate that B7 family contains B7-1, B7-2, B7 homologue1 (B7-H1), B7 dendritic cell molecule (B7-DC), B7-H2, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7, which have costimulatory or coinhibitory effects on T cells. Some of them play an important role in immune regulation in schistosomiasis and the research progress of the B7 family in the immune regulation during schistosome infection is summarised in this paper.

Key words: Schistosoma japonicum, B7 family, Immune regulation

CLC Number:

R532.21

CHEN Guo, ZHU Dan-dan, DUAN Yi-nong. Research progress of immune regulation protein B7 family on immune regulation during Schistosoma japonicum infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(6): 774-779.

Figures/Tables 2

References 49

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配体	别名	受体	作用
B7-1	CD80	CD28 CTLA-4	共刺激共抑制
B7-2	CD86	CD28 CTLA-4	共刺激共抑制
B7-H1	PD-L1、CD274	PD-1（CD279）	共抑制
B7-DC	PD-L2、CD273	PD-1（CD279）	共抑制
B7-H2	ICOSL、B7RP-1、 CD275	ICOS （CD278） CD28 CTLA-4	共刺激共刺激未知
B7-H3	CD276、B7RP-2	未知	共抑制
B7-H4	VTCN1、B7x、B7S1	未知	共抑制
B7-H5	VISTA、PD-1H	未知	共抑制
B7-H6	NCR3LG1	NKp30	共刺激
B7-H7	HHLA2	TMIGD2（CD28H）未知	共刺激共抑制