Heterogeneity of the immune microenvironment in hepatic alveolar echinococcosis and its impact on disease progression

doi:10.12140/j.issn.1000-7423.2025.04.020

Abstract

Abstract:

Hepatic alveolar echinococcosis (HAE), a severe parasitic disease caused by Echinococcus multilocularis larvae infections in the liver, is characterized by high rates of disability and mortality and poses a great threat to both human and animal health. It has been recently found that the immune microenvironment in HAE exhibits considerable heterogeneity, which not only influences host immune responses to parasites, but also poses important impacts on disease progression and clinical manifestations. This article reviews the latest advances in the immune microenvironment of HAE from the perspective of immune microenvironment heterogeneity, discusses the impact on disease progression and proposes future research directions.

Key words: Hepatic alveolar echinococcosis, Immune microenvironment, Heterogeneity, Disease progression

CLC Number:

R532.32

SHI Dalin, PANG Mingquan, WU Defang, XU Xiaolei, WANG Cheng, FAN Haining. Heterogeneity of the immune microenvironment in hepatic alveolar echinococcosis and its impact on disease progression[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(4): 581-587.

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