Anti-Plasmodium activity and mechanisms of antimicrobial peptides

Abstract

Abstract:

Antimicrobial peptides (AMPs) consist of a diverse group of small molecular polypeptides that widely exist in organisms and act as an important part of the innate immune system. AMPs can not only effectively kill bacteria, but also kill fungi, viruses, parasites and even tumor cells. It has been proved that antimicrobial peptides can inhibit the growth of different stages of Plasmodium protozoan and no drug tolerance has been identified so far, making it valuable as a novel anti-malaria agent. Currently, a variety of AMPs with anti-malarial activities have been successively isolated and identified. It includes the AMPs that target Plasmodium within erythrocytes such as dermaseptins and their derivatives dermaseptin S3 and dermaseptin S4, cecropin B and its derivatives SB-37 and Shiva-1, Defensin DefMT2, DefMT3 and DefMT5, etc. Those AMPs targeting the sexual stage of Plasmodium mainly include duramycin, melittin, TP10 and Vida1-Vida3. In this paper, the inhibition effects of AMPs on different developmental stages of Plasmodium and the possible mechanisms are reviewed.

Key words: Antimicrobial peptide, Plasmodium, Mechanism, Anti-malaria agent

CLC Number:

R978.613

Wen-qi ZHENG, Xiu-lan SU. Anti-Plasmodium activity and mechanisms of antimicrobial peptides[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(6): 643-647.

Figures/Tables 2

References 45

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抗菌肽	氨基酸序列	来源	作用阶段与特点
CA(1~13)M(1~13)	KWKLFKKIEKVGQGIGA- VLKVLTTGL	天蚕素与蜂毒肽混合	杀伤红细胞内期的恶性疟原虫^[18]
Dermaseptin DS3	X-ALWKNMLKGIGKLAG- KAALGAVKKLVGAES	索瓦叶泡蛙 Phyllomedusa sauvagii Dermaseptin 衍生物	杀伤红细胞内期的恶性疟原虫^[20]
Dermaseptin DS4	X-ALWMTLLKKVLKAAA- KAALNAVLVGANA	索瓦叶泡蛙 Phyllomedusa sauvagii Dermaseptin 衍生物	杀伤红细胞内期的恶性疟原虫^[21]
Dermaseptin K4K20-S4	ALWKTLLKKVLKAAAK- AALKAVLVGANA	索瓦叶泡蛙 Phyllomedusa sauvagii Dermaseptin S4 衍生物	杀伤红细胞内期的恶性疟原虫^[21]
Dermaseptin K4-S4	ALWMTLLKKVLKA-NH2	索瓦叶泡蛙 Phyllomedusa sauvagii dermaseptin S4 derivative	杀伤红细胞内期的恶性疟原虫^[21]
Dermaseptin NC7-P	H2N-(CH2)6-CO-ALWKTLL- KKVLKA-NH2	索瓦叶泡蛙 Phyllomedusa sauvagii dermaseptin K4-S4(1~13)a 衍生物	杀伤红细胞内期的恶性疟原虫^[22]
SB-37	MPKWKVFKKIEKVGRNIRN- GIVKAGPAIAVLGEAKALG	合成的天蚕素B衍生物	杀伤红细胞内期的恶性疟原虫^[23]
Shiva-1	MPRWRLFRRIDRVGKQIKQ- GILRAGPAIALVGDARAVG	合成的天蚕素B衍生物	杀伤红细胞内期的恶性疟原虫^[23]
DefMT2	GYFCPYNGYCDHHCRKKLRWRGGYCGGRWKLTCICVRG	蓖子硬蜱 Ixodes ricinus	杀伤红细胞内期的恶性疟原虫和夏氏疟原虫^[24,25]
DefMT5	GFFCPYNGYCDRHCRKKLRRRGGYCGGRWKLTCICIMN	蓖子硬蜱 Ixodes ricinus	杀伤红细胞内期的恶性疟原虫和夏氏疟原虫^[24,25]

抗菌肽名称	氨基酸序列	来源	作用阶段与特点
Drosomycin	DCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC	黑腹果蝇	抑制伯氏疟原虫配子体的形成^[28]
Anoplin	GLLKRIKTLLNH2	黄蜂	抑制伯氏疟原虫动合子的形成^{[29, 34]}
天蚕素B	KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKALG	刻克罗普斯蚕蛾	抑制疟原虫卵囊的形成^[17]
防御素A	ATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCRN	埃及伊蚊	抑制鸡疟原虫卵囊的形成^[39]
Gambicin	MVFAYAPTXARXKSIGARYXGYGYLNRK- GVSXDGQTTINSXEDXKRKFGRXSDGFIT	冈比亚按蚊	抑制伯氏疟原虫动合子的形成^[36]
蜂毒肽	X-NH-GIGAVLKVLTTGLPALISWIKRKR- QQCONH2	蜜蜂	抑制伯氏疟原虫动合子的形成^[31]
Mastoparan X	INLKALAALAKKIL	黄蜂	抑制伯氏疟原虫动合子的形成^{[29, 35]}
蛙皮素2	GIGKFLHSAKKFGKAFVGEIMNS	非洲爪蟾	抑制疟原虫动合子的形成^[29]
TP10 (二聚体)	AGYLLGKINLKALAALAKKIL	黄蜂	抑制伯氏疟原虫动合子的形成,抑制恶性疟原虫卵囊的形成^[32]
Vida1	KWKKFKKGIGKLFV	合成的天蚕素B/蜂毒肽衍生物	抑制伯氏疟原虫动合子的形成^[33]
Vida2	KWPKFKKGIPWLFV	合成的天蚕素B/蜂毒肽衍生物	抑制伯氏疟原虫动合子的形成^[33]
Vida3	KWPKFRRGIPFLFV	合成的天蚕素B/蜂毒肽衍生物	抑制伯氏疟原虫动合子的形成^{[29, 33]}
Shiva-1	MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG	合成的天蚕素B 衍生物	抑制伯氏疟原虫动合子与早期子孢子的形成^[37]
Scorpine	GWINEEKIQKKIDERMGNTVLGGMAK- AIVHKMAKNEFQCMANMDMLGNCEK- HCQTSGEKGYCHGTKCKCGTPLSY	非洲帝王蝎	抑制伯氏疟原虫动合子的形成^[38]