Research advances in the regulatory role of non-coding RNA in leishmaniasis

doi:10.12140/j.issn.1000-7423.2023.01.014

Abstract

Abstract:

Leishmania, which can parasitize in the macrophages of humans and animals, causing leishmaniasis, a neglected tropical disease that is estimated to kill up to 40 000 people each year. Non-coding RNA (ncRNA) is a genomic transcript that is not translated into proteins, and plays an important regulatory role in the occurrence and development of a variety of diseases, especially in inflammatory and immune responses. At present, there are few studies on the mechanism of action of ncRNA in leishmaniasis, and the existing studies have shown that in the early stage of Leishmania infection with the host, ncRNA plays an important regulatory role in regulating the proliferation of the parasites in the host and the establishment of infection by regulating antigen presentation, immune response, autophagy, apoptosis. This article reviews the mechanism of action of ncRNA in leishmaniasis, which is critical for the prevention, diagnosis and treatment of leishmaniasis.

Key words: Leishmaniasis, Non-coding RNA, Immune response, Mechanism

CLC Number:

R531.6

JIANG Tiange, ZENG Wenbo, LI Zhongqiu, ZHANG Yi. Research advances in the regulatory role of non-coding RNA in leishmaniasis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(1): 92-97.

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