Research progress on the immune evasion mechanism in Trichinella spiralis infection

doi:10.12140/j.issn.1000-7423.2023.04.016

Abstract

Abstract:

Trichinella spiralis infection can cause zoonotic trichinellosis that seriously endangers human health. During the entire T. spiralis life cycle stages, the parasite can manipulate the host's immune responses. The immune evasion mechanism, as a common natural selection mechanism, is an adaptation of pathogens to the immune system under natural selection. It enables the pathogens to relieve or alleviate the host's immune responses, avoid attacking from the immune system, and ensure that they can survive and reproduce. This paper reviewed the research advance of T. spiralis immune evasion mechanism in disturbing complement response, innate immune response, humoral immune response, and T cell immune response. Further research of the immune evasion mechanism of T. spiralis is of great significance for the prevention and control of trichinosis, the treatment of human autoimmune diseases, and allergic diseases.

Key words: Trichinella spiralis, Immune evasion, Immune response, Immunotherapy

CLC Number:

R383.15

ZHANG Xu, SUN Ximeng. Research progress on the immune evasion mechanism in Trichinella spiralis infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(4): 492-496.

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