Research progress on transcription regulation of rif gene in Plasmodium falciparum

doi:10.12140/j.issn.1000-7423.2023.03.017

Abstract

Abstract:

Plasmodium falciparum-infected erythrocytes express multiple polymorphic proteins known as variant surface antigens, which are associated with symptomatic and severe malaria. The repetitive interspersed family (rif) gene is one of the largest gene families of the P. falciparum multicopy gene families which potentially encode variant antigens. Studying the regulation of rif genes, such as histone modification, repressor element regulation and the involvement of expressed proteins in immune evasion, is of great significance. Based on the current research, we made a comprehensive summary of the rif gene expression regulation mechanisms to understand the pathogenic mechanism of P. falciparum.

Key words: Plasmodium falciparum, rif gene, Transcription regulation, Immune evasion, Transcription repression

CLC Number:

R382.31

XU Shaojie, CHEN Shenbo, CHEN Junhu. Research progress on transcription regulation of rif gene in Plasmodium falciparum[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(3): 374-379.

Figures/Tables 3

References 46

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