Exploration of molecular mechanisms of artemisinin resistance in malaria parasites

Abstract

Abstract:

Malaria is one of the main infectious diseases threatening human health worldwide. Despite the effective control of malaria spread and reduction of mortality by artemisinin-based combination therapy (ACT), Plasmodium falciparum resistance to artemisinin and ACT is increasingly found in recent years. The present review summarizes the molecular mechanisms of artemisinin resistance in P. falciparum including the roles of genes P. falciparum multidrug resistance 1(Pfmdr1), P. falciparum chloroquine resistance transporter (Pfcrt), P. falciparum calcium ATPase 6(Pfatp6), and Pfkelch13, in order to advance our understanding of molecular mechanisms of artemisinin resistance and provide reference for the control and surveillance of spread of artemisinin-resistant malaria parasites.

Key words: Artemisinin, Malaria, Molecular mechanism, Drug resistance, Plasmodium falciparum

CLC Number:

R531.3

Yun-shan MOU, Lu-jie LI, Yin-juan WU, Xue-rong LI. Exploration of molecular mechanisms of artemisinin resistance in malaria parasites[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(6): 636-642.

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