The biological significance of malarial hemozoin’s formation

doi:10.12140/j.issn.1000-7423.2023.02.013

Abstract

Abstract:

The formation of the Plasmodium hemozoin and its biological significance has been controversial. Given that it is closely related to the growth, reproduction and pathogenicity of Plasmodium, the biological function of malarial hemozoin needs to be further elucidated. This article preliminarily discussed the morphology of hemozoin, the formation of hemozoin, the biological function of hemozoin, its relationship with the host macrophages, and its pathogenicity to reveal the role of the formation of hemozoin in the use of heme and iron, the unique function of hemozoin in the evolution, growth, and reproduction of malaria parasites, which helps to clarify the limitations of the traditional understanding of the Plasmodium hemozoin formation. It provides ideas for further understanding the pathogenic mechanism of Plasmodium and developing new antimalarial drugs.

Key words: Plasmodium, Malarial hemozoin, Heme, Iron

CLC Number:

R382.31

SUN Jun. The biological significance of malarial hemozoin’s formation[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(2): 209-212.

Figures/Tables 2

References 31

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