Functions and roles of miRNA during the infection of Anopheles by Plasmodium

doi:10.12140/j.issn.1000-7423.2020.06.011

Abstract

Abstract:

miRNA is a type of single-stranded non-coding RNA with a length of 21-24 bases. miRNA may lead to mRNA degradation or translation inhibition by targeting the 3′-end untranslated region of mRNA, and plays an important role in the defense response of Anopheles against pathogen invasion among many other biological processes. This article reviews the possible functions, and target genes and signaling pathways involved of miRNAs, during Anopheles infection with Plasmodium.

Key words: miRNA, Anopheles, Plasmodium, Function, Regulation

CLC Number:

R382.31

ZHU Ling-qian, FENG Xin-yu, HU Wei, LI Shi-zhu. Functions and roles of miRNA during the infection of Anopheles by Plasmodium[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(6): 742-748.

Figures/Tables 1

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miRNA	疟原虫感染后表达变化	靶基因	功能	蚊媒
miR-1174	下调^[12]	丝氨酸羟甲基转移酶^[17]	调节相关的肠道功能,包括血液摄取、体液排泄和糖吸收^[17]	冈比亚按蚊（Anopheles gambiae）^[12,17]
MiR-276		支链氨基酸转移酶（BCAT）^[21]	蚊子的繁殖周期和恶性疟原虫（Plasmodium falciparum）的发育^[21]	An. coluzzii^[21]
miR-305	上调^[14]	可能调控已知的抗疟原虫效应基因^[14]	恶性疟原虫（P. falciparum）的发育、肠微生物群的免疫力^[14]	冈比亚按蚊（An. gambiae）^[14]
miR-989	上调^[14]	潜在的候选基因:STAT蛋白抑制剂（PIAS）^[20]	中肠疟原虫发育的激动剂^[20]	冈比亚按蚊（An. gambiae）^[14]斯氏按蚊（An. stephensi）^[20]
miR-34	下调^[12]	抗氧化1（OXR1）^[20]胸腺素同工型2（Thymosin isoform 2）^[20]	疟原虫发育^[20]	冈比亚按蚊（An. gambiae）^[12]斯氏按蚊（An. stephensi）^[20]
miR-275	下调^[22]	amino acid/target of rapamycin(AA/TOR),20-羟基蜕皮激素^[23]	与疟原虫感染有关^[22]参与埃及伊蚊中的卵子发育,体液排泄,血液消化^[23]	嗜人按蚊（An. anthropophagus）^[22]