Research advance and application of whole-genome sequencing of Plasmodium

doi:10.12140/j.issn.1000-7423.2021.02.021

Abstract

Abstract:

Malaria is an infectious disease caused by Plasmodium infection and one of the most important public health problems in the world. With the completion of human malaria parasite genome sequence and the development of sequencing technology, the whole-genome sequencing is becoming increasingly useful in determining parasite evolution, revealing epidemic characteristics, drug resistance surveillance, and genetic tracking. This paper reviews the advances in research on and application of the whole-genome sequencing technology for studies on Plasmodium.

Key words: Malaria, Plasmodium, Whole-genome sequencing

CLC Number:

R382.31

LIU Hong, LIU Yao-bao, CAO Jun. Research advance and application of whole-genome sequencing of Plasmodium[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(2): 265-270.

Figures/Tables 1

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疟原虫种	基因组大小/Mb	染色体数量	AT含量/%	Scaffolds数	基因总数^[11]	蛋白质编码基因数^[11]
恶性疟原虫^[10]	23.3	14	80.7	14	5 712	5 460
间日疟原虫^[7]	29.1	14	60.3	374	6 830	6 677
三日疟原虫^[9]	33.6	14	75.3	63	6 709	6 573
卵形疟原虫柯氏亚种^[9,10]	33.5	14	71.6	4 025	7 280	7 162
卵形疟原虫沃氏亚种^[9,10]	33.5	14	71.1	1 914	8 582	8 421
诺氏疟原虫^[8]	24.4	14	61.3	28	5 483	5 323