CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2022, Vol. 40 ›› Issue (6): 786-791.doi: 10.12140/j.issn.1000-7423.2022.06.015

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Research progress of amodiaquine as an antimalarial drug

ZHAO Hui1(), XIANG Zheng1, ZHOU Long-can2, PAN Mao-hua2, YANG Zhao-qing1()   

  1. 1. Kunming Medical University, Kunming 650500, China
    2. The People’s Hospital of Shanglin, Guangxi 530000, China
  • Received:2022-04-22 Revised:2022-10-10 Online:2022-12-30 Published:2022-12-21
  • Contact: YANG Zhao-qing E-mail:18435226968@163.com;zhaoqingy92@hotmail.com
  • Supported by:
    National Science Foundation of China(U1802286);National Science Foundation of China(31860604);Science and Technology Planning Project of Yunnan Science and Technology Department(202003AE140004);Research Project of Health Commission of Guangxi Zhuang Autonomous Region(ZA20221274)

Abstract:

Malaria is a serious, life-threatening infectious disease caused by the Plasmodium parasite. The treatment and prevention of malaria mainly rely on antimalarial drugs. Amodiaquine is an important drug for the treatment and prevention of malaria. It is used in combination with artemisinin dericatives as a first-line treatment drug in many countries where malaria is endemic including Africa. This article reviews the unique antimalarial activity, treatment outcomes, molecular markers for drug resistance and safety of amodiaquine.

Key words: Amodiaquine, Malaria

CLC Number: