Progress on parasite tubulin

Abstract

Abstract:

Parasites threaten the health of humans and animals, so there is an imperative need for pharmaceutical control and treatment of parasitic infection. The anti-parasite drugs targeting the microtubules of parasites have attracted much attention. In this article, we summarize the properties of microtubules, their interactions with drugs, resistance to drugs, as well as the experimental methods, in order to provide theoretical basis for exploring new anti-parasite drugs.

Key words: Parasite, Tubulin, Inhibitor, Mode of action, Drug resistance, Experimental methods

CLC Number:

Jia-qing YAO, Cong-shan LIU, Hao-bing ZHANG. Progress on parasite tubulin[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(2): 180-184.

References 60

[1]	诸欣平, 苏川. 人体寄生虫学[M]. 北京:人民卫生出版社, 2013.
[2]	黄艳, 余新炳. 食源性寄生虫病流行趋势、研究与发展方向[J]. 中国寄生虫学与寄生虫病杂志, 2015, 33(6): 436-442.
[3]	李英俊, 张经京. 苯并咪唑类化合物生物活性的研究进展[J]. 化学工程与装备, 2013(8): 175-177.
[4]	孟江平, 耿蓉霞, 周成合, 等. 苯并咪唑类药物研究进展[J]. 中国新药杂志, 2009, 18(16): 1505-1514.
[5]	梁闻, 王新春, 吴向未, 等. 阿苯达唑壳聚糖微球抗小鼠细粒棘球蚴药效实验研究[J]. 中国寄生虫学与寄生虫病杂志, 2014, 32(3): 188-192.
[6]	刘丛珊, 张皓冰. 甲苯达唑治疗棘球蚴病的疗效、代谢及生物利用度的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2009, 27(6): 513-519.
[7]	Nogales E.Structural insight into microtubule function[J]. Annu Rev Biophys Biomol Struct, 2001, 30(1): 397-420.
[8]	Subramanian R, Kapoor TM.Building complexity: insights into self-organized assembly of microtubule-based architectures[J]. Dev Cell, 2012, 23(5): 874-885.
[9]	Cumino AC, Elissondo MC, Denegri GM.Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces[J]. Parasitol Int, 2009, 58(3): 270-277.
[10]	谭小宁, 金芳, 李志超, 等. 靶向微管抗肿瘤药物研究进展[J]. 生命科学研究, 2013, 17(1): 90-94.
[11]	Tydén E, Engström A, Morrison DA, et al. Sequencing of the β-tubulin genes in the ascarid nematodes Parascaris equorum and Ascaridia galli[J]. Mol Biochem Parasitol, 2013, 190(1): 38-43.
[12]	Nogales E, Wang HW.Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives[J]. Curr Opin Struct Biol, 2006, 16(2): 221-229.
[13]	Pasquier E, Kavallaris M.Microtubules: a dynamic target in cancer therapy[J]. IUBMB Life, 2008, 60(3): 165-170.
[14]	Shaw SL, Kamyar R, Ehrhardt DW.Sustained microtubule tread milling in Arabidopsis cortical arrays[J]. Science, 2003, 300(5626): 1715-1718.
[15]	Banora MY, Rodiuc N, Baldacci-Cresp F, et al. Feeding cells induced by phytoparasitic nematodes require γ-tubulin ring complex for microtubule reorganization[J]. PLoS Pathog, 2011, 7(12): e1002343.
[16]	Oakley BR.An abundance of tubulins[J]. Trends Cell Biol, 2000, 10(12): 537-542.
[17]	Davis C, Gull K.Protofilament number in microtubules in cells of two parasitic nematodes[J]. J Parasitol, 1983, 69(6): 1094-1099.
[18]	Chalfie M, Thomson JN.Structural and functional diversity in the neuronal microtubules of Caenorhabditis elegans[J]. J Cell Biol, 1982, 93(1): 15-23.
[19]	Cottingham K.A new PTM for tubulin is found in a parasite[J]. J Proteome Res, 2010, 9(1): 4-5.
[20]	Dumontet C, Jordan MA.Microtubule-binding agents: a dynamic field of cancer therapeutics[J]. Nat Rev Drug Discov, 2010, 9(10): 790-803.
[21]	Pusztai L. Markers predicting clinical benefit in breast cancer from microtubule-targeting agents[J]. Ann Oncol, 2007, 18 Suppl 12: xii15-20.
[22]	刘翎, 刘宗英, 李卓荣. 作用于秋水仙碱结合位点的微管蛋白抑制剂研究进展[J]. 中国新药杂志, 2012, 21(16): 1892-1899.
[23]	Nanavaty V, Lama R, Sandhu R, et al. Orally active and selective tubulin inhibitors as anti-trypanosome agents[J]. PLoS One, 2016, 11(1): e0146289.
[24]	Mottier L, Alvarez L, Ceballos L, et al. Drug transport mechanisms in helminth parasites: passive diffusion of benzimidazole anthelmintics[J]. Exp Parasitol, 2006, 113(1): 49-57.
[25]	高学军, 李庆章. 苯并咪唑氨基甲酸酯类抗蠕虫药物作用机制研究进展[J]. 东北农业大学学报, 2004, 35(4): 492-495.
[26]	Jasmer DP, Yao C, Rehman A, et al. Multiple lethal effects induced by a benzimidazole anthelmintic in the anterior intestine of the nematode Haemonchus contortus[J]. Mol Biochem Parasitol, 2000, 105(1): 81-90.
[27]	Robinson MW, McFerran N, Trudgett A, et al. A possible model of benzimidazole binding to beta-tubulin disclosed by invoking an inter-domain movement[J]. J Mol Graph Model, 2004, 23(3): 275-284.
[28]	张吉丽, 李冰, 周绪正, 等. 动物抗寄生虫药物作用机理研究进展[J]. 中国畜牧兽医, 2016, 43(1): 242-247.
[29]	Márquez-Navarro A, Pérez-Reyes A, Zepeda-Rodríguez A, et al. RCB20, an experimental benzimidazole derivative, affects tubulin expression and induces gross anatomical changes in Taenia crassiceps cysticerci[J]. Parasitol Res, 2013, 112(6): 2215-2226.
[30]	Douglas K.Approaches to design and synthesis of antiparasitic drugs, by Satyavan Sharma (edited by Nitya Anand)[J]. Parasitol Today, 1999, 15(3): 329.
[31]	高成庄, 李焱. 苯并咪唑衍生物的特性及应用研究进展[J]. 郑州轻工业学院学报(自然科学版), 2007, 22(2): 35-36, 57.
[32]	何迎盈. 苯并咪唑类药物抗肿瘤研究进展[J]. 重庆医学, 2011, 40(27): 2796-2798.
[33]	王文娜. 新型苯并咪唑类微管蛋白抑制剂的设计、合成及活性研究[D]. 长春: 吉林大学, 2014.
[34]	Wolstenholme AJ, Fairweather I, Prichard R, et al. Drug resistance in veterinary helminths[J]. Trends Parasitol, 2004, 20(10): 469-476.
[35]	Aguayo-Ortiz R, Méndez-Lucio O, Romo-Mancillas A, et al. Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model[J]. J Mol Graph Model, 2013, 45: 26-37.
[36]	Drudge JH, Szanto J, Wyant ZN, et al. Field studies on parasite control in sheep: comparison of thiabensazole, ruelene, and phenothiazine[J]. Am J Vet Res, 1964, 25: 1512-1518.
[37]	郭仁民. 家畜寄生蠕虫抗药性及对策[J]. 青海畜牧兽医杂志, 1997, 27(1): 32-34.
[38]	Tzelos T, Matthews J.Anthelmintic resistance in equine helminths and mitigating its effects[J]. In Practice, 2016, 38(10): 489-499.
[39]	江晓胜. 人体寄生蠕虫的抗药性: 家畜蠕虫病防治中所存在问题的启示[J]. 国外医学寄生虫病分册, 1998, 25(3): 139-140.
[40]	Stark D, Barratt JL, Roberts T, et al. Activity of benzimidazoles against Dientamoeba fragilis(Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance[J]. Parasite, 2014, 21: 41.
[41]	Chakrabarti R, Rawat PS, Cooke BM, et al. Cellular effects of curcumin on Plasmodium falciparum include disruption of microtubules[J]. PLoS One, 2013, 8(3): e57302.
[42]	Roos MH, Kwa MSG, Grant WN.New genetic and practical implications of selection for anthelmintic resistance in parasitic nematodes[J]. Parasitol Today, 1995, 11(4): 148-150.
[43]	Beech RN, Prichard RK, Scott ME.Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus[J]. Genetics, 1994, 138(1): 103-110.
[44]	Dos Santos JM, Monteiro JP, Ribeiro WL, et al. Identification and quantification of benzimidazole resistance polymorphisms in Haemonchus contortus isolated in Northeastern Brazil[J]. Vet Parasitol, 2014, 199(3-4): 160-164.
[45]	毛小勇, 华倩倩, 李相志, 等. 抗弓形虫β微管蛋白小分子抗原肽多克隆抗体的制备及鉴定[J]. 中国寄生虫学与寄生虫病杂志, 2014, 32(4): 322-323.
[46]	Brehm K, Kronthaler K, Jura H, et al. Cloning and characterization of beta-tubulin genes from Echinococcus multilocularis[J]. Mol Biochem Parasitol, 2000, 107(2): 297-302.
[47]	Geary TG, Nulf SC, Favreau MA, et al. Three β-tubulin cDNAs from the parasitic nematode Haemonchus contortus[J]. Mol Biochem Parasitol, 1992, 50(2): 295-306.
[48]	Gerhold RW, Lollis LA, McDougald LR, et al. Partial sequence of the alpha-tubulin gene from Histomonas meleagridis isolates from the United States[J]. J Parasitol, 2011, 97(2): 354-356.
[49]	赵殷奇, 李子华, 王浩, 等. 细粒棘球绦虫原头节抗原分子Eg-01883的克隆、表达及免疫原性分析[J]. 中国寄生虫学与寄生虫病杂志, 2016, 34(3): 208-213.
[50]	孙敏, 何深一, 赵广会, 等. 刚地弓形虫14-3-3蛋白真核表达载体的构建与表达[J]. 中国寄生虫学与寄生虫病杂志, 2012, 30(6): 438-441.
[51]	Oxberry ME, Geary TG, Winterrowd CA, et al. Individual expression of recombinant alpha- and beta-tubulin from Haemonchus contortus: polymerization and drug effects[J]. Protein Expr Purif, 2001, 21(1): 30-39.
[52]	Ashraf M, Srivastava M, Ghorui SK, et al. Cloning and sequence analysis of β-tubulin gene of Trypanosoma evansi isolates from Indian dromedaries (Camelus dromedarius)[J]. Indian J Anim Res, 2015, 49(5): 618-622.
[53]	Dustin P.Microtubules[J]. Sci Am, 1980, 243(2): 66-76.
[54]	Tsai AC, Wang CY, Liou JP, et al. Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib[J]. Cell Death Dis, 2014, 5: e1162.
[55]	Prudent R, Vassal-Stermann É, Nguyen CH, et al. Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities[J]. Br J Pharmacol, 2013, 168(3): 673-685.
[56]	Cai D, Qiu Z, Yao W, et al. YSL-12, a novel microtubule-destabilizing agent, exerts potent anti-tumor activity against colon cancer in vitro and in vivo[J]. Cancer Chemother Pharmacol, 2016, 77(6): 1217-1229.
[57]	Lin HY, Li ZK, Bai LF, et al. Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization[J]. Biochem Pharmacol, 2015, 96(2): 93-106.
[58]	Prota AE, Danel F, Bachmann F, et al. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization[J]. J Mol Biol, 2014, 426(8): 1848-1860.
[59]	乔会晶, 戴子茹, 葛广波, 等. 分子对接技术在新药研发领域中的应用进展[J]. 南阳师范学院学报, 2015, 14(12): 29-35.
[60]	Sharma OP, Pan A, Hoti SL, et al. Modeling, docking, simulation, and inhibitory activity of the benzimidazole analogue against β-tubulin protein from Brugia malayi for treating lymphatic filariasis[J]. Med Chem Res, 2011, 21(9): 2415-2427.