Research progress on the structure and function of tick-derived serine protease inhibitor containing Kunitz domains

doi:10.12140/j.issn.1000-7423.2023.05.015

Abstract

Abstract:

Ticks are blood-sucking ectoparasites. During their blood-sucking process, ticks release variou anticoagulant substances to the hosts to facilitate blood meal. Serine protease inhibitors containing Kunitz domains play an important role in anticoagulation. Different Kunitz serine protease inhibitors have similar conserved sequences but with different overall structures. In the coagulation cascade, inhibition of one or more serine proteases can block the activation of downstream coagulation factors, which could achieve the effect of inhibiting coagulation. Targets for different tick-derived Kunitz serine protease inhibitors in the blood clotting system are varied, and so do their inhibitory mechanisms. To summarize, the anticoagulant targets and anticoagulation mechanisms of those protease inhibitors could contribute to the research and development of anticoagulant and antithrombotic drugs. They could further explain the interaction between ticks and their hosts and the pharmacological action of tick-derived anticoagulant drugs. This can also prevent the invasion of ticks to their hosts.

Key words: Tick, Kunitz type serine protease inhibitor, Anticoagulant

CLC Number:

384.41

LIU Yueqing, MA Linyuan, CHEN Kaiting, GAO Jinliang, WANG Peng. Research progress on the structure and function of tick-derived serine protease inhibitor containing Kunitz domains[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(5): 625-630.

Figures/Tables 1

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