The role of innate immunity in defending against infection with Cryptosporidium parvum

Abstract

Abstract:

Cryptosporidium parvum is an important pathogen that causes diarrhea in humans, especially in children < 2 years. Because of the“minimally invasive” nature of Cryptosporidium parasites, the innate immune responses mediated by epithelial cells are critical for the host to defend against infection, particularly infection with Cryptosporidium. In this review, we focus on the effector molecules secreted by epithelial cells, pattern recognition receptor activation, miRNA regulation, exosome release, and the complement system, in order to elucidate the mechanisms underlying the role of innate immunity in defending against infection with Cryptosporidium parvum.

Key words: Cryptosporidium parvum, Epithelial cell, Innate immunity, NF-κB signaling pathway

CLC Number:

R382.3

Xiao-jie LIU, Tie-bo MAO, Rui ZHOU. The role of innate immunity in defending against infection with Cryptosporidium parvum[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(2): 185-192.

Figures/Tables 1

References 86

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