CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2017, Vol. 35 ›› Issue (2): 173-179.

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Advances on the infection of parasites in treating inflammatory bowel diseases

Hui-wen XU1,2, Jian-ping CAO3, Kui-yang ZHENG1, Wei PAN1,*()   

  1. 1 Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou 221004, China
    2 Department of Clinical Medicine, Xuzhou Medical University, Xuzhou 221004, China
    3 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China
  • Received:2016-09-01 Online:2017-04-20 Published:2017-05-02
  • Contact: Wei PAN E-mail:panwei525@126.com
  • Supported by:
    Supported by the National Natural Science Foundation of China(No. 81501762), Natural Science Fund of the Jiangsu Higher Education Institutions(No. 15KJB310025), Jiangsu Planned Projects for Postdoctoral Research Funds(No. 1501061A), and Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Province(No. 201510313017, 201510313017Z)

Abstract:

Epidemiological evidence has shown that the morbidity of inflammatory bowel disease in human is negatively correlated with the infection rate of parasites, indicating a therapeutic potential of parasite infection for inflammatory bowel disease. There have been explorations on a switch from parasite elimination to using their excretory-secretory products to develop safe and effective inflammatory bowel disease therapies. This review summarizes the therapeutic effectiveness of parasite infection models in the treatment of inflammatory bowel disease and the underlying mechanisms.

Key words: Inflammatory bowel disease, Parasite, Immune mechanism

CLC Number: