›› 1997, Vol. 15 ›› Issue (4): 208-211.

• 论著 • Previous Articles     Next Articles

REDUCTION OF SCHISTOSOMA JAPONICUM INFECTION IN AN ENDEMIC AREA IN ISLET WITH EMBANKMENT AFTER PROPHYLAXISWITH ORAL ARTEMETHER THROUGHOUT THE TRANSMISSION SEASON

Tian Ziying1; Xiao Shuhua2; Xiao Junwen1; Zhou Yincai1; L iu Deshan1; Zheng
Jiang2; Chen Minggang2; Qu Guishun1; Zhang Xiaoyun1; Yao Xiaoming1; Zhang Xianzhong1; Zhang
Delin3; Wang Gexian3   

  1. 1　Changde Anti-schistosomiasis station, Changde City , Hunan Province, Changde 415000 2　Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025 3　Office for Schistosomiasis Control of Hanshou County, Changde City , Hunan Province, Hanshou 415900
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-08-30 Published:1997-08-30

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Abstract: AIM:To study the prophylactic effect of oral artemether on protecting people from
Schistosoma japonicum infection in an endemic area located in an islet with embankment.
METHODS:789villagers aged 5 - 6 0 years were allocated randomly to artemether (Art) and the
control group by pairing method. The egg- positive rates in Art group and the control group were
comparable (2 9.5 % vs 2 9.2 % ) . The firstdose of artemether 6 mg/ kg was given in the first
ten- day of June to the villagers who had contacted the infested-water within 15 days, followed by repeated dosing once every 15 days for 9 times. The villagers in the control group were treated with placebo concurrently. Fecal examination was made for the 2 groups one month after the last medication for evaluation of preventive effect. RESULTS: In artemether group 5 out of 290 villagers who had completed 9 times of medication showed egg-positive with an infection rate of 1. 7% , while in the control group , 82 out of 305 were positive with an infection rate of 26. 9%. The difference between the 2 groups was statistically significant. CONCLUSION: The villagers in the schistosomiasis endemic area, an islet with embankment, were protected from superinfection of S. japonicum by administering artemether throughout the whole transmission season.

Key words: Schistosoma japonicum, prophylaxis of schistosomiasis, schistosomal infection rate, artemether