恶性疟原虫重复散布家族基因转录调控的研究进展

doi:10.12140/j.issn.1000-7423.2023.03.017

中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (3): 374-379.doi: 10.12140/j.issn.1000-7423.2023.03.017

恶性疟原虫重复散布家族基因转录调控的研究进展

徐少杰(), 陈绅波, 陈军虎^*()

中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），世界卫生组织热带病合作中心，科技部国家级热带病国际联合研究中心，国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，上海 200025

收稿日期:2022-10-12 修回日期:2023-04-24 出版日期:2023-06-30 发布日期:2023-05-30
通讯作者: *陈军虎（1978-），男，博士，研究员，从事重要媒传寄生虫感染与宿主免疫、诊断、疫苗研究。E-mail：chenjh@nipd.chinacdc.cn
作者简介:徐少杰（1997-），男，硕士研究生，从事寄生虫病防治研究。E-mail：xushaojie0420@163.com
基金资助:
国家重点研发计划(2018YFE0121600)

Research progress on transcription regulation of rif gene in Plasmodium falciparum

XU Shaojie(), CHEN Shenbo, CHEN Junhu^*()

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research; NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China

Received:2022-10-12 Revised:2023-04-24 Online:2023-06-30 Published:2023-05-30
Contact: *E-mail: chenjh@nipd.chinacdc.cn
Supported by:
National Key Research and Development Program of China(2018YFE0121600)

摘要/Abstract

摘要：

恶性疟原虫在人体内编码变异型表面抗原，可能引起其对人体进行免疫逃避。重复散布家族（rif）基因是编码变异型表面抗原的第一大家族，研究rif基因的调控如组蛋白修饰、阻遏元件调节、表达蛋白参与了免疫逃避等，具有很重要的意义。本文对调控rif基因机制的相关的研究进展进行综述，以期探究恶性疟原虫的致病过程。

关键词: 恶性疟原虫, rif基因, 转录调控, 免疫逃避, 转录抑制

Abstract:

Plasmodium falciparum-infected erythrocytes express multiple polymorphic proteins known as variant surface antigens, which are associated with symptomatic and severe malaria. The repetitive interspersed family (rif) gene is one of the largest gene families of the P. falciparum multicopy gene families which potentially encode variant antigens. Studying the regulation of rif genes, such as histone modification, repressor element regulation and the involvement of expressed proteins in immune evasion, is of great significance. Based on the current research, we made a comprehensive summary of the rif gene expression regulation mechanisms to understand the pathogenic mechanism of P. falciparum.

Key words: Plasmodium falciparum, rif gene, Transcription regulation, Immune evasion, Transcription repression

中图分类号:

R382.31

徐少杰, 陈绅波, 陈军虎. 恶性疟原虫重复散布家族基因转录调控的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(3): 374-379.

XU Shaojie, CHEN Shenbo, CHEN Junhu. Research progress on transcription regulation of rif gene in Plasmodium falciparum[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(3): 374-379.

图/表 3

参考文献 46

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恶性疟原虫重复散布家族基因转录调控的研究进展

Research progress on transcription regulation of rif gene in Plasmodium falciparum

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