›› 1997, Vol. 15 ›› Issue (6): 388-391.

• 实验报道 • Previous Articles     Next Articles

TUMOR NECROSISFACTOR ENHANCESMACROPHAGE- MEDIATED KILLING OF PLASMODIUM YOELII

Zhang Haiyan1; Li Huizhu2; Niu Yuxin3; Wang Fengyun2   

  1. 1 Departmentof Cytobiology, Capital University of Medical sciences, Beijing 100054 2 Department of parasitology, Capital University of Medical sciences, Beijing 1000543 Department of biology, Capital University of Medical sciences, Beijing 100054
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-12-28 Published:1997-12-28

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Abstract: AIM:To observe the effects of tumor necrosis factor (TNF) on the receptor expression and the capacity
for phagocytosing Plasmodium yoelii by peritoneal macrophages. METHODS:The Fc receptor and C3b receptor were
determined by m PAPmethod and YC rosette assay,respectively. RESULTS:After the pretreatment of macrophages with
different concentrations of TNF in vitro for 5 h, TNF showed a significant increase both in the percentage of
phagocytosis of P.yoelii parasitized erythrocytes by macrophages, and in the expression of Fc receptor and the rate of YC rosette formation on macrophage. CONCLUSION: TNF might increase the expressions of Fc and C3b receptors, which lead to increased phagocytosis of parasites by macrophage.

Key words: Tumor necrosis factor, macrophage, Plasmodium yoelii, Fc receptor, C3b receptor, phagocytosi