Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis

doi:10.12140/j.issn.1000-7423.2025.05.016

Abstract

Abstract:

Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by infection with Echinococcus multilocularis larvae in hosts. As an exogenous substance, persistent larval E. multilocularis infections lead to suppression of cellular immune functions and dysregulation of cytokine secretion in hosts, thereby creating a unique immunosuppressive microenvironment in hosts. As a key anti-inflammatory cytokine, interleukin-10 (IL-10) plays a pivotal role in the immunomodulation of echinococcosis. This review presents the formation of the immunosuppressive microenvironment of AE, analyzes the biological characteristics of IL-10, its regulatory effects on immune cell functions, and its interplay with other cytokines, and discusses the mechanisms of the contribution of IL-10 to shaping the immunosuppressive microenvironment of AE, so as to provide new theoretical evidence for AE treatment and potential therapeutic targets of AE.

Key words: Alveolar echinococcosis, Immunosuppression, Immune microenvironment, Interleukin 10

CLC Number:

R532.32

WANG Shujun, HAN Fei, ZHANG Huixia, ZHONG Shigui, ZHAO Yumin. Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(5): 705-710.

Figures/Tables 1

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