Analysis of the current status of Clonorchis sinensis infection in Xinfeng County, Jiangxi Province from 2020 to 2022

doi:10.12140/j.issn.1000-7423.2024.05.015

Abstract

Abstract:

In order to understand the current situation of Clonorchis sinensis infection in Xinfeng County, Jiangxi Province, Xinfeng County was divided into 5 sectors (east, west, south, north and central) according to the geographical location. From each sector, 1 administrative village in 1 township (town) was selected as surveillance site, and no less than 200 permanent residents aged 3 or above were selected by cluster random sampling from each surveillance site in every year. Fecal samples were collected and examined for eggs of C. sinensis by modified Kato-Katz thick smear method (two slides per sample). The infected cases were treated with praziquantel (75 mg/kg) for 2 days, and examined for eggs of C. sinensis one month after treatment. The infection rate was compared by Chi-square test. The total infection rate of C. sinensis was 6.43% (202/3 142) in Xinfeng County from 2020 to 2022, and the annual infection rates were 6.09% (61/1 002), 5.11% (52/1 017) and 7.93% (89/1 123), respectively (χ² = 7.30, P < 0.05). The infection rate of males (8.30%, 134/1 614) was higher than females (4.45%, 68/1 528) (χ² = 19.36, P < 0.01). The infection rates of the elderly groups over 40 years old (7.87%, 168/2 134) was higher than that of the younger age groups (3.37%, 34/1 008) (χ² = 23.04, P < 0.01). The groups with the highest infection rates were college and above in 2020 (1/8), junior high school in 2021 (6.02%, 15/249) and illiteracy in 2022 (11.36%, 30/264), respectively. The infected cases originated from 176 households, and the proportions of households with 1, 2 and 4 infected cases were 87.50% (154/176), 11.36% (20/176) and 1.14% (2/176), respectively. After praziquantel treatment, 197 infected cases achieved negative in fecal test, among them 2 cases turned positive after 1 year and 10 cases turned positive after 2 years. The reinfection rate was 6.09% (12/197). The results indicated that the prevention and control situation for clonorchiasis in Xinfeng County, Jiangxi Province was still severe. The infection rates were relatively high in some administrative villages, with familial clustering of infection and individual reinfection.

Key words: Clonorchis sinensis, Infection status, Family infection, Reinfection, Jiangxi Province

CLC Number:

R532.23

LAN Weiming, ZENG Yufeng, QIU Tingting, ZHOU Changhai, CHEN Zhe, GE Jun, ZENG Xiaojun, ZHU Tingjun. Analysis of the current status of Clonorchis sinensis infection in Xinfeng County, Jiangxi Province from 2020 to 2022[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024, 42(5): 659-663.

Figures/Tables 2

References 15

[1]	Qian MB, Chen YD, Zhou XN. From recognition to practice: The 140th anniversary of the discovery of Clonorchis sinensis[J]. Chin J Parasitol Parasit Dis, 2014, 32(4): 247-252. (in Chinese)
	(钱门宝, 陈颖丹, 周晓农. 从认识到实践: 纪念华支睾吸虫发现140周年[J]. 中国寄生虫学与寄生虫病杂志, 2014, 32(4): 247-252.)
[2]	Zeng XJ, Li ZJ, Jiang WS, et al. Survey of epidemic status of principal human parasites in Jiangxi Province in 2014[J]. Chin J Schisto Control, 2015, 27(6): 595-599. (in Chinese)
	(曾小军, 李召军, 姜唯声, 等. 2014年江西省人体重点寄生虫感染现状[J]. 中国血吸虫病防治杂志, 2015, 27(6): 595-599.)
[3]	Lan WM, Jiang WS, Dai KJ, et al. Analysis of infective status of Clonorchis sinensis in Jiangxi Province[J]. Chin J Schisto Control, 2017, 29(1): 44-47. (in Chinese)
	(兰炜明, 姜唯声, 戴坤教, 等. 江西省人体华支睾吸虫感染现状分析[J]. 中国血吸虫病防治杂志, 2017, 29(1): 44-47.)
[4]	Ge J, Jiang WS, Yuan CH, et al. The achievements of 3-year efforts of clonorchiasis control in the demonstration area of Xinfeng County in Jiangxi Province[J]. Chin J Parasitol Parasit Dis, 2020, 38(5): 554-560. (in Chinese)
	(葛军, 姜唯声, 袁长红, 等. 江西省信丰县华支睾吸虫病综合防治示范区3年防治成效[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 554-560.) doi: 10.12140/j.issn.1000-7423.2020.05.005
[5]	Yuan CH, Lan MX, Zhu TJ, et al. Analysis on the status of human infection in national surveillance sites for clonorchiasis in Xinfeng County during 2016-2019[J]. Chin J Parasitol Parasit Dis, 2020, 38(5): 561-565. (in Chinese)
	(袁长红, 蓝明兴, 诸廷俊, 等. 2016—2019年江西省信丰县人群华支睾吸虫病国家监测点人群感染情况分析[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 561-565.) doi: 10.12140/j.issn.1000-7423.2020.05.006
[6]	Qian MB, Utzinger J, Keiser J, et al. Clonorchiasis. Lancet, 2016, 387(10020): 800-810.
[7]	Zhu TJ, Chen YD, Qian MB, et al. Surveillance of clonorchiasis in China in 2016[J]. Acta Trop, 2020, 203: 105320.
[8]	Expert Group of National Center for Infectious Diseases, National Center for Infectious Disease Medicine. Expert consensus on diagnosis and treatment of foodborne parasitic diseases (2023)[J]. Chin J Parasitol Parasit Dis, 2023, 41(6): 653-668. (in Chinese)
	(国家感染性疾病临床医学研究中心, 国家传染病医学中心撰写组. 食源性寄生虫病诊治专家共识(2023)[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(6): 653-668.) doi: 10.12140/j.issn.1000-7423.2023.06.001
[9]	Chen Z, Zhu TJ, Ye B, et al. Epidemiological survey on clonorchiasis and awareness of prevention and control knowledge in Xinfeng County of Jiangxi Province[J]. Chin J Schisto Control, 2018, 30(5): 508-512. (in Chinese)
	(陈喆, 诸廷俊, 叶斌, 等. 江西省信丰县华支睾吸虫病和防治相关知识知晓情况调查[J]. 中国血吸虫病防治杂志, 2018, 30(5): 508-512.)
[10]	Wang X, Wang BH, Wang SY, et al. Current status of clonorchiasis infection in key areas of western Jilin Province in 2021[J]. Chin J Public Health Eng, 2023, 32(6): 786-788, 791. (in Chinese)
	(王心, 王本贺, 王姝雅, 等. 2021年吉林省西部重点地区华支睾吸虫病感染现状[J]. 中国卫生工程学, 2023, 32(6): 786-788, 791.)
[11]	Wang KY, Shu HF, Fang YY, et al. Data analysis of clonorchiasis surveillance in high endemic areas of Guangdong Province in 2016-2020[J]. Chin J Parasitol Parasit Dis, 2022, 40(5): 629-634. (in Chinese)
	(王可艺, 舒黄芳, 方悦怡, 等. 2016—2020年广东省华支睾吸虫病高流行地区人群感染监测分析[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(5): 629-634.) doi: 10.12140/j.issn.1000-7423.2022.05.010
[12]	Wei YL, Cai RR, Ye LH, et al. Investigation and analysis of Clonorchis sinensis infection in Guangxi population in 2020[J]. Appl Prev Med, 2022, 28(4): 374-376. (in Chinese)
	(韦毅柳, 蔡日荣, 叶路红, 等. 2020年广西人群华支睾吸虫感染情况调查分析[J]. 应用预防医学, 2022, 28(4): 374-376.)
[13]	Yuan S, Tang L, Ge T, et al. Analysis of Paragonimus hepatica infection in Heilongjiang Province in 2020[J]. J Med Pest Contr, 2023, 39(2): 195-197. (in Chinese)
	(袁爽, 唐磊, 葛涛, 等. 2020年黑龙江省肝吸虫感染状况分析[J]. 医学动物防制, 2023, 39(2): 195-197.)
[14]	Fang YY, Chen YD, Li XM, et al. Current prevalence of Clonorchis sinensis infection in endemic areas of China[J]. Chin J Parasitol Parasit Dis, 2008, 26(2): 99-103, 109. (in Chinese)
	(方悦怡, 陈颖丹, 黎学铭, 等. 我国华支睾吸虫病流行区感染现状调查[J]. 中国寄生虫学与寄生虫病杂志, 2008, 26(2): 99-103, 109.)
[15]	Zeng XJ, Chen HG, Jiang WS, et al. Studies on infection of intestinal parasites and bio-epidemiology of ascaris in rural area of Jiangxi Province[J]. J Pathog Biol, 2001, 14(4): 265-267. (in Chinese)
	(曾小军, 陈红根, 姜唯声, 等. 江西省农村居民肠道寄生虫感染调查及蛔虫生物流行病学研究[J]. 中国寄生虫病防治杂志, 2001, 14(4): 265-267.)

监测点	2020年		2021年			2022年
监测点	检查人数	感染人数（感染率/%）	检查人数	感染人数（感染率/%）		检查人数	感染人数（感染率/%）
樟塘^a,b	200	19（9.50）	201	15（7.46）		263	25（9.51）
黄泥^a,b	200	0（0）	200	0（0）		200	0（0）
焦坑^a,b	202	42（20.79）	201	22（10.95）		260	41（15.77）
余村^a/太平^b	200	0（0）	200	0（0）		200	3（1.50）
正坳^a/小河^b	200	0（0）	215	15（6.98）	200		20（10.00）
合计	1 002	61（6.09）	1 017	52（5.11）		1 123	89（7.93）

特征	2020年		2021年		2022年		合计
特征	检查人数	感染人数（感染率/%）	检查人数	感染人数（感染率/%）	检查人数	感染人数（感染率/%）	检查人数	感染人数（感染率/%）
性别
男	522	37（7.09）	514	36（7.00）	578	61（10.55）	1 614	134（8.30）
女	480	24（5.00）	503	16（3.18）	545	28（5.14）	1 528	68（4.45）
年龄组/岁
3~9	59	1（1.69）	67	1（1.49）	75	1（1.33）	201	3（1.49）
10~19	109	5（4.59）	106	3（2.83）	199	2（1.01）	414	10（2.42）
20~29	48	6（12.50）	44	0（0）	57	4（7.02）	149	10（6.71）
30~39	58	2（3.45）	82	3（3.66）	104	6（5.77）	244	11（4.51）
40~49	189	14（7.41）	162	10（6.17）	152	21（13.82）	503	45（8.95）
50~59	246	16（6.50）	256	19（7.42）	247	22（8.91）	749	57（7.61）
60~69	174	10（5.75）	176	10（5.68）	165	19（11.52）	515	39（7.57）
70及以上	119	7（5.88）	124	6（4.84）	124	14（11.29）	367	27（7.36）
文化程度
文盲	204	8（3.92）	310	16（5.16）	264	30（11.36）	778	54（6.94）
小学	355	19（5.35）	303	17（5.61）	294	19（6.46）	952	55（5.78）
初中	341	24（7.04）	249	15（6.02）	352	31（8.81）	942	70（7.43）
高中、中专或中技	94	9（9.57）	126	4（3.17）	147	7（4.76）	367	20（5.45）
大专及以上	8	1（1/8）	29	0（0）	66	2（3.03）	103	3（2.91）