Research advances on the inhibition of interferon-γ-dependent cellular immunity by Toxoplasma gondii

Abstract

Abstract:

It has been reported that Toxoplasma gondii, after invading mouse cells, secrets a virulence factor ROP18 to bind and phosphorylate immunity-related p47 GTPase (IRG), inhibiting its binding to parasitophorous vacuole membrane (PVM) and thus the breakage of the parasitophorous vacuole (PV), enabling the growth and proliferation of T. gondii in the PVs. In contrast to the elucidation of immune escape mechanism of T. gondii in mouse cells, little is known in human cells. It is reported that the ubiquitin-labeled PVs can fuse with the lysosomal system in human cells, which results in death of T. gondii tachyzoits by acidification. This review summarizes the mechanisms by which T. gondii inhibits cellular immunity, especially the interferon-γ-dependent cellular immunity in host cells. In our understanding of immune evasion of T. gondii through blocking ubiquitination of PVs, recent advances are reviewed as well.

Key words: Toxoplasma gondii, Interferon-γ, Cellular immunity, Immune evasion, Ubiquitin

CLC Number:

R382.5

Li-jie YAO, Hong-juan PENG. Research advances on the inhibition of interferon-γ-dependent cellular immunity by Toxoplasma gondii[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(5): 503-508.

Figures/Tables 1

References 55

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