Abstract: In the process of invasion and development in host cells，Toxoplasma gondii causes acute and chronic infection. The parasite manipulates the host cell elaborately and integrately to keep a delicate balance between induction and elimanation of the host cell immune reaction. It can then dwell and multiply successfully in the host cell，and hopefully be transmitted to a definitive host. The host cell signaling is changed and regulated extensively by the parasite in the process，which plays vital roles in parasite invasion and development. This review shed light on the manipulation of host cell signaling by T. gondii infection in these aspects：① T. gondii secreted proteins which manipulate host cell signaling； ② T. gondii modulates the innate and protective immune related host cell signaling；③ T. gondii regulates anti-apoptotic reaction and cell cycle related host cell signaling；④ T. gondii adjusts calcium relevant host cell signaling；⑤ T. gondii manipulates cell structure reorganization relevant host cell signaling.

Key words: Toxoplasma gondii, Invasion, Development, Host cell, Cell signal