Abstract: 　AIM:To observe the histopathological changes of Echinococcus granulosus cysts in mice treated with liposomal albendazole and co administration with cimetidine by light microscopy and electron microscopy. METHODS:An oral dose of liposomal ABZ with different formulations was given at 200 mg/kg·d.Cimetidine was administered daily at an oral dose of 100 mg/kg·d. Sixty seven mice were orally given different drugs six days per week for a total of twelve weeks. RESULTS: The histopathological changes indicated that there were significant differences ( P <0.01) between treated groups and control group. The degeneration and necrosis of E.granulosus cysts were marked in liposomal albendazole combined with cimetidin group. CONCLUSION:Liposomal albendazole was more effective against E.granulosus cyst than albendazole. Cimetidine had an apparent synergistic effect when given in combination with liposomal albendazle.

Key words: Animal experiment, Echinococcus granulosus, liposomal albendazole, transmission electron microscope