›› 1998, Vol. 16 ›› Issue (1): 6-28.

• 论著 • Previous Articles     Next Articles

EFFECT OF ARTEMETHER ON HEXOKINASE, GLUCOSE PHOSPHATE ISOMERASE AND PHOSPHOFRUCTOKINASE OF SCHISTOSOMA JAPONICUM HARBORED IN MICE *

Xiao Shuhua; You Jiqing; Guo Huifang; Jiao Peiying; Mei Jingyan; Yao Minyi; Feng Zheng   

  1. Institute of Parasitic Diseases; Chinese Academy of Preventive Medicine; WHO Collaborating Center of Malaria; Schistosomiasis and Filariasis; Shanghai 200025
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-02-28 Published:1998-02-28

Abstract: AIM:To study the effect of artemether(Art) on hexokinase(HK),glucose phosphate isomerase(GPI)and phosphofructokinase(PFK)of Schistosoma japonicum . METHODS:Mice infected with schistosome cercariae for 4-5 wk were treated ig with Art 100 or 300 mg·kg -1 and killed 24 h or 48 h after medication for collection of schistosomes.The activities of HK,GPI and PFK of the worms were determined by measuring the formation of NADPH or consumption of NAD...

Key words: Schistosoma japonicum, artemether, hexokinase, glucose phosphate isomerase, phosphofructokinase