›› 1996, Vol. 14 ›› Issue (1): 37-41.

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PRESENT STATUS OF THE SENSITIVITY OF PLASMODIUM FALCIPARUM  TO ANTIMALARIALS IN CHINA

Liu Dequan1, Liu Ruijun1, Zhang Chunyong1, Cai Xianzheng2, Tang Xian2, Yang Henglin3, Yang Pinfang3, Dong Ying3   

  1. 1 Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025
    2 Hainan Institute of Tropical Diseases, Haikou 570203
    3 Yunnan Institute of Malaria, Simao 665000
  • Online:1996-02-28 Published:2017-01-02

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Abstract: AIM: To assess the sensitivity of Plasmodium falciparum to antimalarials. METHOD: WHO standard in vitro microtest was used. RESULTS: Except for the absence of resistance to mefloquine and quinine, the resistance rate of the parasite to chloroquine, amodiaquine and piperaquine was 84.6%, 86.1% and 38.0% respectively. Plasmodium falciparum in 8 3% of the cases showed resistance to pyronaridine. CONCLUSION: Among the antimalarials tested in Hainan and Yunnan, high resistance of P.falciparum to chloroquine, amodiaquine and piperaquine was found. The sensitivity of P.falciparum in a few cases to pyronaridine and artemisinin and its derivatives was decreased. Cross resistance between some of the antimalarials has been evidenced.

Key words: Plasmodium falciparum, resistance, sensitivity, chloroquine, amodiaquine, piperaquine, pyronaridine, artemisinin and its derivatives