Research progress on detection technology of Echinococcus and echinococcosis

doi:10.12140/j.issn.1000-7423.2019.03.019

Abstract

Abstract:

Echinococcosis is a chronic parasitic disease caused by the infection of Echinococcus larvae. Due to the complex life cycle involved with a large number of hosts, it is very challenging to control the spread of infection and eliminate echinococcosis. Early and accurate detection of Echinococcus parasite, real-time monitoring of various types of host infection are very critical for blocking the epidemic and the transmission of the disease. This paper reviews the recent advances in the detection technology for Echinococcus parasite and the related research on the diagnosis of echinococcosis, including morphological identification, imaging diagnosis, immunological and molecular biology diagnostic techniques, in order to provide useful information for the advanced detection of Echinococcus infections and diagnosis of echinococcosis.

Key words: Echinococcosis, Echinococcus, Detection, Diagnosis

CLC Number:

R532.32

Hong-rang ZHOU, Mu-xin CHEN, Ying WANG, Qing YU, Ning XIAO. Research progress on detection technology of Echinococcus and echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019, 37(3): 346-352.

References 74

[1]	Torgerson PR, Keller K, Magnotta M, et al. The global burden of alveolar echinococcosis[J]. PLoS Negl Trop Dis, 2010, 4(6): e722.
[2]	Brunetti E, Kern P, Vuitton DA, et al. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans[J]. Acta Trop, 2010, 114(1): 1-16.
[3]	Budke CM, Peter D, Torgerson PR.Global socioeconomic impact of cystic echinococcosis[J]. Emerg Infect Dis, 2006, 12(2): 296.
[4]	张梦媛, 伍卫平, 官亚宜, 等. 我国棘球蚴病疾病负担分析[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(1): 15-19, 25.
[5]	曾祥嫚, 王立英, 伍卫平, 等. 我国非青藏高原流行区囊型棘球蚴病聚类分析[J]. 中国血吸虫病防治杂志, 2014, (2): 180-183.
[6]	Eckert J, Deplazes P.Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern[J]. Clin Microbiol Rev, 2004, 17(1): 107-135.
[7]	伍卫平, 王虎, 王谦, 等. 2012-2016年中国棘球蚴病抽样调查分析[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(1): 1-14.
[8]	伍卫平. 我国两型包虫病的流行与分布情况[J]. 中国动物保健, 2017, 19(7): 7-9.
[9]	Carmena D, Cardona GA.Canine echinococcosis: global epidemiology and genotypic diversity[J]. Acta Trop, 2013, 128(3): 441-460.
[10]	Conraths FJ, Deplazes P.Echinococcus multilocularis: epidemiology, surveillance and state-of-the-art diagnostics from a veterinary public health perspective[J]. Veter Parasitol, 2015, 213(3-4): 149-161.
[11]	Restrepo AMC, Yang YR, Mcmanus DP, et al. The landscape epidemiology of echinococcoses[J]. Infect Dis Poverty, 2016, 5(1): 13.
[12]	刘辉, 肖宁, 杨诗杰, 等. 青藏高原地区犬棘球绦虫感染的流行病学特征[J]. 中国血吸虫病防治杂志, 2017, 29(2): 129-138.
[13]	孟庆贺. 我国包虫病的诊断和治疗进展[J]. 中国城乡企业卫生, 2014, 29(5): 16-18.
[14]	王虎, 阎海玉, 武海燕. 青海高原不同宿主体内原头节的透射电镜观察[J]. 地方病通报, 1994, (3): 19-21.
[15]	曾诚, 韩秀敏, 蔡慧霞, 等. 青海省青南高原与柴达木盆地细粒棘球蚴实验感染犬体内成虫形态学比较观察[J]. 中国病原生物学杂志, 2006, 1(4): 257-259.
[16]	Aoki T, Hagiwara M, Yabuki H, et al. Unique MRI findings for differentiation of an early stage of hepatic alveolar echinococcosis[J]. Case Reports, 2015, 2015(feb19 1): bcr2014208123-bcr2014208123.
[17]	Surgery B.CT scanning in identification of sheep cystic echinococcosis[J]. Biomed Res Int, 2017, 2017: 1-6.
[18]	Liu H, Zhang C, Fan X, et al. Robust phase-retrieval-based X-ray tomography for morphological assessment of early hepatic echinococcosis infection in rats[J]. PLoS One, 2017, 12(9): e183396.
[19]	曾红春, 王颖鑫, 王俊华, 等. 大鼠感染肝泡状棘球蚴不同时期超声动态演变与病理对照研究[J]. 中国医学影像学杂志, 2016, 24(5): 325-328.
[20]	Osimani JJ, Migliaro EF, Abella CM.Experimental study of the effect of ultrasonics on the larva of Echinococcus granulosus (hydatid cyst)[J]. Ann Parasitol Hum Comp, 1953, 28(1/2): 33-46.
[21]	Gharbi HA, Hassine W, Brauner MW, et al. Ultrasound examination of the hydatic liver[J]. Radiol, 1981, 139(2): 459-463.
[22]	Aubry G, Tillier H, Massonnat J, et al. Vertebrocostal echinococco-sis: presentation of specimen and X-ray pictures[J]. Alger Medicale, 1952, 56(10): 712-719.
[23]	Koufakis T, Margaritis A.Right upper quadrant pain: a case where diagnosis was made from the chest X-ray[J]. Pan Afr Med J, 2014, 17(1): 60.
[24]	Shah T, Geyt JL, Atkins J.Let sleeping dogs lie: a surprising chest X-ray in the paediatric emergency department[J]. Case Rep, 2014, 2014(apr25 1). DOI:10.1136/bcr-2014-203973
[25]	Akgul OC, Onat S.Computed tomography (CT) findings of pulmonary hydatid cysts in children and the factors related to cyst rupture[J]. Med Sci Monit, 2017, 23: 3679-3686.
[26]	Sreedevi C, Devi MA, Annapurna P, et al. A rare case of spleenic hydatidosis in a buffalo: patho-morphological study[J]. J Parasitic Dis, 2016, 40(1): 1-3.
[27]	Tackmann K, Mattis R, Conraths FJ.Detection of Echinococcus multilocularis in foxes: evaluation of a protocol of the intestinal scraping technique[J]. J Vet Med B Infect Dis Vet Public Health, 2006, 53(8): 395-398.
[28]	Duscher G, Prosl H, Joachim A.Scraping or shaking--a comparison of methods for the quantitative determination of Echinococcus multilocularis in fox intestines[J]. Parasitol Res, 2005, 95(1): 40-42.
[29]	Umhang G, Woronoff-Rhen N, Combes B, et al. Segmental sedimentation and counting technique (SSCT): an adaptable method for qualitative diagnosis of Echinococcus multilocularis in fox intestines[J]. Exp Parasitol, 2011, 128(1): 57-60.
[30]	刘学庭, 黄月菊. 多房性棘球绦虫原头蚴生成、发育和繁殖的形态学观察[J]. 诊断病理学杂志, 2002, 9(4): 234-235.
[31]	Sarī C, Ertug S, Karadam SY, et al. The comparative evaluation of enzyme linked immunosorbent assay (ELISA), indirect hemagglutination test (IHA) and indirect fluorescent antibody test (IFAT) in the diagnosis of cystic echinococcosis[J]. Turkiye Parazitol Derg, 2009, 33(1): 73-76.
[32]	朱兵, 徐明谦, 温浩, 等. 包虫病人唾液特异性抗体的检测研究与应用[J]. 中国人兽共患病学报, 2001, 17(3): 55-57.
[33]	Ravinder P, Parija SK.Urinary hydatid antigen detection by coagglutination, a cost-effective and rapid test for diagnosis of cystic echinococcosis in a rural or field setting[J]. J Clin Microbiol, 2000, 38(8): 2972.
[34]	Otero-Abad B, Armua-Fernandez MT, Deplazes P, et al. Latent class models for Echinococcus multilocularis diagnosis in foxes in Switzerland in the absence of a gold standard[J]. Parasites Vectors, 2017, 10(1): 612.
[35]	Shariff M, Parija SC.Co-agglutination (Co-A) test for circulating antigen in hydatid disease[J]. J Med Microbiol, 1993, 38(6): 391-394.
[36]	Azazy AA, Abdelhamid AH.Indirect haemagglutination (IHA) for the diagnosis of hydatid disease in Yemen[J]. J Egypt Soc Parasitol, 2000, 30(2): 407-411.
[37]	Devi CS, Parija SC.Latex agglutination test (LAT) for antigen detection in the cystic fluid for the diagnosis of cystic echinococcosis[J]. Diagn Microbiol Infect Dis, 2003, 45(2): 123-126.
[38]	钱丽, 张彤. 包虫病人唾液抗体的三种免疫学检测方法比较[J]. 疾病预防控制通报, 1999, 14(4): 13-15.
[39]	Dabaghzadeh H, Bairami A, Kia EB, et al. Seroprevalence of human cystic echinococcosis in Alborz province, central Iran in 2015[J]. Iran J Public Health, 2018, 47(4): 561-566.
[40]	Challacombe SJ, Russell MW, Hawkes J.Passage of intact IgG from plasma to the oral cavity via crevicular fluid[J]. Clin Exp Immunol, 1978, 34(3): 417-422.
[41]	景涛, 赵玉元. 包虫病人新鲜唾液与冰冻保存唾液中特异性抗体活性的检测[J]. 兰州大学学报: 医学版, 1994, (2) : 77-79
[42]	Sunita T, Khurana S, Malla N, et al. Immunodiagnosis of cystic echinocooccosis by antigen detection in serum, urine, and saliva samples[J]. Trop Parasitol, 2010, 1(1): 33-38.
[43]	钱丽, 姜国枢. 应用McAb法检测包虫病人尿液抗原[J]. 疾病预防控制通报, 1999, 14(3): 23-25.
[44]	Parija SC, Ravinder PT, Rao KS.Detection of hydatid antigen in urine by countercurrent immunoelectrophoresis[J]. J Clin Microbiol, 1997, 35(6): 1571.
[45]	Sadaka HA, Khalifa AM, Eldein SZ, et al. Urinary antigen detection for diagnosis of hydatid disease[J]. J Egypt Soc Parasitol, 2002, 32(1): 69.
[46]	叶刚强, 苏丹虹. 协同凝集试验在胆囊棘蚴病的诊断应用[J]. 广东医学, 2001, 22(10): 909-910.
[47]	Sakalar Ç, Kuk S, Erensoy A, et al. Molecular discrimination of Echinococcus granulosus and Echinococcus multilocularis by sequencing and a new PCR-RFLP method with the potential use for other Echinococcus species[J]. Turk J Med Sci, 2014, 44(5): 741.
[48]	Spotin A, Majdi MMA, Sankian M, et al. The study of apoptotic bifunctional effects in relationship between host and parasite in cystic echinococcosis: a new approach to suppression and survival of hydatid cyst[J]. Parasitol Res, 2012, 110(5): 1979-1984.
[49]	Dore F, Varcasia A, Pipia AP, et al. Ultrasound as a monitoring tool for cystic echinococcosis in sheep[J]. Veter Parasitol, 2014, 203(1/2): 59-64.
[50]	曾诚. 青海省青南高原棘球绦虫新种-石渠棘球绦虫的形态学观察[J]. 现代预防医学, 2013, 40(7): 1354-1356.
[51]	Jeyathilakan N, Basith SA, John L, et al. Evaluation of native 8 kDa antigen based three immunoassays for diagnosis of cystic echinococcosis in sheep[J]. Small Ruminant Res, 2014, 116(2/3): 199-205.
[52]	Sheeba A, Sangaran A, Latha BR.Diagnosis of cystic echinococcosis in buffaloes by native 8 kDa antigen using latex agglutination test (LAT)[J]. J Parasitic Dis, 2016, 40(4):1401-1405.
[53]	Dinkel A, Kern S, Brinker A, et al. A real-time multiplex-nested PCR system for coprological diagnosis of Echinococcus multilocularis and host species[J]. Parasitol Res, 2011, 109(2): 493-498.
[54]	Karamon J.Detection of Echinococcus multilocularis in faeces by nested PCR with the use of diluted DNA samples[J]. Pol J Veter Sci, 2014, 17(1): 79-83.
[55]	Knapp J, Millon L, Mouzon L, et al. Real time PCR to detect the environmental faecal contamination by Echinococcus multilocularis from red fox stools[J]. Veter Parasitol, 2014, 201(1-2): 40-47.
[56]	Raja CB,Myriam OM,Selim M, et al.A novel PCR-RFLP assay for molecular characterization of Echinococcus granulosus sensu lato and closely related species in developing countries[J]. Parasitol Res, 2016, 115(10): 1-8.
[57]	Onac D, Györke A, Oltean M, et al. First detection of Echinococcus granulosus G1 and G7 in wild boars (Sus scrofa) and red deer (Cervus elaphus) in Romania using PCR and PCR-RFLP techniques[J]. Veter Parasitol, 2013, 193(1/3): 289-291.
[58]	Alam-Eldin YH, Abdel Aaty HE, Ahmed MA.Molecular characterization of cystic echinococcosis: first record of G7 in Egypt and G1 in Yemen[J]. Acta Parasitol, 2015, 60(4): 662.
[59]	蔡辉霞, 王虎, 韩秀敏, 等. 青海高原棘球绦虫不同宿主感染情况及意义的研究[J]. 中华地方病学杂志, 2012, 31(3): 296-300.
[60]	Bagrade G, Deksne G, OzoliNa Z, et al. Echinococcus multilocularis in foxes and raccoon dogs: an increasing concern for Baltic countries[J]. Parasit Vectors, 2016, 9(1): 615.
[61]	Soares MDCP, Souza AJSD, Malheiros AP, et al. Neotropical echinococcosis: second report of Echinococcus vogeli natural infection in its main definitive host, the bush dog (Speothos venaticus)[J]. Parasitol Int, 2013, 63(2): 485-487.
[62]	李燕兵, 袁芳, 李红卫, 等. 粪便检查在包虫病传染源调查中的应用[J]. 宁夏医科大学学报, 2010, 32(1): 147-150.
[63]	Goffredo G, Susanna K, Alberto B, et al. Investigation on the occurrence of Echinococcus multilocularis in central Italy[J]. Bmc Veter Res, 2009, 5(1): 44.
[64]	Adediran OA, Kolapo TU, Uwalaka EC.Echinococcus granulosus prevalence in dogs in Southwest Nigeria[J]. J Parasitol Res, 2014, 2014: 124358.
[65]	Aljawabreh A, Dumaidi K, Ereqat S, et al. Incidence of Echinococcus granulosus in domestic dogs in palestine as revealed by Copro-PCR[J]. PLoS Negl Trop Dis, 2015, 9(7): e3934.
[66]	Santa MA, Pastran SA, Claudia K, et al. Detecting co-infections of Echinococcus multilocularis and Echinococcus canadensis in coyotes and red foxes in Alberta, Canada using real-time PCR[J]. Int J Parasitol Parasites Wildl, 2018, 7(2): 111-115.
[67]	Wassermann M, Mackenstedt U, Romig T.A loop-mediated isothermal amplification (LAMP) method for the identification of species within the Echinococcus granulosus complex[J]. Veter Parasitol, 2014, 200(1-2): 97-103.
[68]	Ni X, Mcmanus DP, Yan H, et al. Loop-mediated isothermal amplification (LAMP) assay for the identification of Echinococcus multilocularis infections in canine definitive hosts[J]. Parasit Vectors, 2014, 7(1): 254.
[69]	Ahmed ME, Eldigail MH, Elamin FM, et al. Development and evaluation of real-time loop-mediated isothermal amplification assay for rapid detection of cystic echinococcosis[J]. Bmc Veter Res, 2016, 12(1): 202.
[70]	Lass A, Szostakowska B, Myjak P, et al. The first detection of Echinococcus multilocularis DNA in environmental fruit, vegetable, and mushroom samples using nested PCR[J]. Parasitol Res, 2015, 114(11): 4023-4029.
[71]	Umhang G, Bastien M, Renault C, et al. A flotation/sieving method to detect Echinococcus multilocularis and Toxocara spp. eggs in soil by real-time PCR[J]. Parasite, 2017, 24: 28.
[72]	Robertson LJ, Troell K, Woolsey ID, et al. Fresh fruit, vegetables, and mushrooms as transmission vehicles for Echinococcus multilocularis in Europe: inferences and concerns from sample analysis data from Poland[J]. Parasitol Res, 2016, 115(6): 2485-2488.
[73]	刘文朝, 李连香, 王华, 等. 包虫病区农牧民饮水安全实用技术探讨[J]. 中国农村水利水电, 2017, (3): 180-182.
[74]	Umhang G, Comte S, Hormaz V, et al. Retrospective analyses of fox feces by real-time PCR to identify new endemic areas of Echinococcus multilocularis in France[J]. Parasitol Res, 2016, 115(11): 1-5.