慢性刚地弓形虫感染对宿主神经精神和行为的影响

doi:10.12140/j.issn.1000-7423.2025.03.019

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (3): 429-435.doi: 10.12140/j.issn.1000-7423.2025.03.019

慢性刚地弓形虫感染对宿主神经精神和行为的影响

施承雨¹()(), 昌运晶¹, 吕芳丽¹^,²^,^*()()

1 中山大学医学院寄生虫学教研室，广东深圳 518107
2 中山大学附属第七医院科研中心，广东深圳 518107

收稿日期:2024-11-05 修回日期:2025-04-18 出版日期:2025-06-30 发布日期:2025-06-26
通讯作者: *吕芳丽（ORCID：0009-0002-6812-4133），女，医学博士，教授，从事弓形虫相关研究工作。E-mail：lvfangli@mail.sysu.edu.cn
作者简介:施承雨（ORCID：0009-0008-0887-2766），男，本科生。E-mail：shichy9@mail2.sysu.edu.cn
基金资助:
国家自然科学基金面上项目(82272366);国家自然科学基金面上项目(81971955);深圳市自然科学基金面上项目(JCYJ20220530145002006);广东省自然科学基金面上项目(2021A1515012115);广东省自然科学基金面上项目(2019A1515011667)

Impact of chronic Toxoplasma gondii infection on host neuropsychiatric and behavioral well-being

SHI Chengyu¹()(), CHANG Yunjing¹, LV Fangli¹^,²^,^*()()

1 Department of Parasitology, School of Medicine, Sun Yat-sen University, Shenzhen 518107, Guangdong, China
2 Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, Guangdong, China

Received:2024-11-05 Revised:2025-04-18 Online:2025-06-30 Published:2025-06-26
Contact: *E-mail: lvfangli@mail.sysu.edu.cn
Supported by:
National Natural Science Foundation of China(82272366);National Natural Science Foundation of China(81971955);Shenzhen Municipal Natural Science Foun-dation(JCYJ20220530145002006);Natural Science Foundation of Guangdong Province(2021A1515012115);Natural Science Foundation of Guangdong Province(2019A1515011667)

摘要/Abstract

摘要：

刚地弓形虫（简称弓形虫）是一种全球分布的专性细胞内寄生原虫，可引起人兽共患的弓形虫病。研究发现，慢性弓形虫感染通过在宿主脑中形成组织包囊，导致宿主的中枢神经系统功能损伤（如神经免疫应答和神经递质失衡），表现为精神障碍（如精神分裂症、双向情感障碍、重度抑郁和自杀未遂）、认知功能下降、阿尔茨海默病和行为改变（如致命的吸引现象、交通事故风险增高、成为狼王的概率增加、性吸引力增加以及饮食偏好改变）等。本文旨在探究慢性弓形虫感染与宿主神经精神和行为改变的关联及其潜在机制。

关键词: 刚地弓形虫, 慢性感染, 神经精神, 行为, 机制

Abstract:

Toxoplasma gondii is a globally distributed obligate intracellular parasite that causes zoonotic toxoplasmosis. Studies have found that chronic T. gondii infection leads to damage of the host’s central nervous system (such as altered neuroimmune response and neurotransmitter imbalance) through the formation of tissue cysts in the host brain, manifested as changes in mental disorders (such as schizophrenia, bipolar affective disorder, major depression, and suicide attempts), cognitive decline, Alzheimer’s disease, and behavioral changes (such as fatal attraction phenomenon, increased risk of traffic accidents, increased probability of becoming a wolf king, increased sexual attractiveness, and changes in dietary preferences), etc. This review aims to explore the relationship and underlying mechanisms between chronic T. gondii infection and host neuropsychiatric and behavioral changes.

Key words: Toxoplasma gondii, Chronic infection, Neuropsychiatric, Behavior, Mechanisms

中图分类号:

R531.8

施承雨, 昌运晶, 吕芳丽. 慢性刚地弓形虫感染对宿主神经精神和行为的影响[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(3): 429-435.

SHI Chengyu, CHANG Yunjing, LV Fangli. Impact of chronic Toxoplasma gondii infection on host neuropsychiatric and behavioral well-being[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(3): 429-435.

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慢性刚地弓形虫感染对宿主神经精神和行为的影响

Impact of chronic Toxoplasma gondii infection on host neuropsychiatric and behavioral well-being

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