顶复门原虫蛋白质二硫键异构酶研究进展

doi:10.12140/j.issn.1000-7423.2025.03.018

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (3): 423-428.doi: 10.12140/j.issn.1000-7423.2025.03.018

顶复门原虫蛋白质二硫键异构酶研究进展

王璐阳()(), 张乾, 张素梅, 张龙现^*()()

河南农业大学动物医学院，河南郑州 450002

收稿日期:2024-12-25 修回日期:2025-02-10 出版日期:2025-06-30 发布日期:2025-05-27
通讯作者: *张龙现（ORCID：0000-0001-9310-1975），男，博士，教授，从事人兽共患寄生虫病入侵机制及分子流行病学研究。E-mail：zhanglx8999@henau.edu.cn
作者简介:王璐阳（ORICD：0000-0002-6103-3821），男，博士研究生，从事人兽共患肠道原虫病入侵机制研究。 E-mail：wly952659965@foxmail.com
基金资助:
国家自然科学基金(32172882)

Progress of researches on the structure and biological functions of protein disulfide isomerase in apicomplexan protozoa

WANG Luyang()(), ZHANG Qian, ZHANG Sumei, ZHANG Longxian^*()()

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, Henan, China

Received:2024-12-25 Revised:2025-02-10 Online:2025-06-30 Published:2025-05-27
Contact: *E-mail: zhanglx8999@henau.edu.cn
Supported by:
National Natural Science Foundation of China(32172882)

摘要/Abstract

摘要：

顶复门原虫是一类专性细胞内寄生虫，多数为人兽共患病病原，其宿主范围广泛，可对畜牧养殖业造成巨大经济损失并严重威胁公共卫生安全。现有研究表明，蛋白质二硫键异构酶（PDI）广泛存在于顶复门原虫中，主要与寄生虫的入侵、黏附和细胞免疫有关，在寄生虫的生长发育过程中发挥重要的作用。本文对近年来已报道的顶复门原虫PDI的结构和生物学功能进行综述，以期为寄生虫病的防控和疫苗研发提供理论依据和新的策略。

关键词: 顶复门原虫, 蛋白质二硫键异构酶, 酶结构, 生物学功能

Abstract:

Apicomplexan protozoa are a class of obligate intracellular parasites, and most of them are pathogens of zoonoses, with a wide range of hosts, causing huge economic losses to the livestock breeding industry and posing great threats to public health security. It has been demonstrated that protein disulfide isomerase (PDI) is widely present in apicomplexan protozoa, which is mainly associated with the invasion, adhesion and cellular immunity of parasites and plays an important role in the growth and development process of parasites. This review summarizes the advances in the structure and biological functions of PDI in apicomplexan protozoa, so as to provide insights into management of parasitic diseases and research and development of vaccines against parasitic diseases.

Key words: Apicomplexan protozoa, Protein disulfide isomerase, Enzyme structure, Biological function

中图分类号:

R382

王璐阳, 张乾, 张素梅, 张龙现. 顶复门原虫蛋白质二硫键异构酶研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(3): 423-428.

WANG Luyang, ZHANG Qian, ZHANG Sumei, ZHANG Longxian. Progress of researches on the structure and biological functions of protein disulfide isomerase in apicomplexan protozoa[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(3): 423-428.

图/表 2

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顶复门原虫蛋白质二硫键异构酶研究进展

Progress of researches on the structure and biological functions of protein disulfide isomerase in apicomplexan protozoa

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