miRNA在顶复门寄生虫感染中调控作用的研究进展

doi:10.12140/j.issn.1000-7423.2023.06.013

摘要/Abstract

摘要：

miRNA是一种人和动物体内含量丰富的小型单链非编码RNA，可调控细胞能量代谢、细胞增殖和凋亡、肿瘤发生和病毒入侵等过程。顶复门寄生虫是一种严格寄生于细胞内的专性原虫。近年的研究发现，miRNA在顶复门寄生虫感染过程中起重要的调控作用。miRNA不仅可作为一种新型标志物，用于监测寄生虫病的发生、发展、诊断和预后，还作为新型调控因子参与宿主与寄生虫的相互作用，影响宿主细胞的正常生理过程。本文对miRNA在顶复门寄生虫感染中的调控作用机制进行综述，以期为探索顶复门寄生虫病的预防、诊断和治疗方法提供参考。

关键词: 顶复门, 寄生虫, miRNA, 作用机制

Abstract:

miRNAs are abundant small non-coding single-stranded RNAs in animals, including humans, that play crucial roles in regulating cellular processes such as cell energy metabolism, proliferation, apoptosis, tumorigenesis, and viral invasion. Apicomplexan parasites are strictly intracellular parasitic protozoa that exhibit host specificity and infect a wide range of hosts. Recent research has revealed the significant regulatory roles of miRNAs during the infection process of apicomplexan parasites. miRNAs serve as novel biomarkers for monitoring the occurrence, development, diagnosis, and prognosis of parasitic diseases and act as novel regulators involved in the interplay between host cells and parasites. This interaction affects the normal physiological processes of host cells and consequently impacts the overall functionality of the organism. This review article summarizes the regulatory mechanisms of miRNAs during apicomplexan parasite infections, aiming to provide valuable insights for exploring preventive, diagnostic, and therapeutic approaches against apicomplexan parasitic diseases.

Key words: Apicomplexan, Parasites, miRNA, Mechanism

中图分类号:

R382

马悦, 赵保才, 周佳丽, 胡峻豪, 赵洪喜. miRNA在顶复门寄生虫感染中调控作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(6): 749-755.

MA Yue, ZHAO Baocai, ZHOU Jiali, HU Junhao, ZHAO Hongxi. Research progress on the regulation of miRNA in the infection of apicomplexan parasites[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(6): 749-755.

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