miRNA在疟原虫感染按蚊过程中的功能及作用

doi:10.12140/j.issn.1000-7423.2020.06.011

中国寄生虫学与寄生虫病杂志 ›› 2020, Vol. 38 ›› Issue (6): 742-748.doi: 10.12140/j.issn.1000-7423.2020.06.011

miRNA在疟原虫感染按蚊过程中的功能及作用

朱凌倩(), 冯欣宇, 胡薇, 李石柱^*()

中国疾病预防控制中心寄生虫病预防控制所,国家热带病研究中心,世界卫生组织热带病合作中心,科技部国家级热带病国际联合研究中心,卫生部寄生虫病原与媒介生物学重点实验室,上海 200025

收稿日期:2020-06-11 出版日期:2020-12-30 发布日期:2021-01-12
通讯作者: 李石柱
作者简介:朱凌倩（1993-）,女,硕士研究生,从事媒传疾病分子生物学研究。E-mail: zhulingqian721@163.com
基金资助:
国家自然科学基金青年项目(81802039);国家传染病重大专项(2016ZX10004222-004)

Functions and roles of miRNA during the infection of Anopheles by Plasmodium

ZHU Ling-qian(), FENG Xin-yu, HU Wei, LI Shi-zhu^*()

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention;Chinese Center for Tropical Diseases Research;WHO Collaborating Centre for Tropical Diseases;National Center for International Research on Tropical Diseases, Ministry of Science and Technology;Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai 200025, China

Received:2020-06-11 Online:2020-12-30 Published:2021-01-12
Contact: LI Shi-zhu
Supported by:
Youth Program of National Natural Science Foundation of China(81802039);National Key Program for Infectious Disease of China(2016ZX10004222-004)

摘要/Abstract

摘要：

miRNA是一类长度约21~24个碱基的单链非编码RNA,通过靶向mRNA 3′端非翻译区结合导致mRNA降解或翻译抑制,在按蚊对入侵病原体的防御反应等多种生物学过程中均发挥重要功能。本文就miRNA在疟原虫感染按蚊过程中可能发挥的功能、所涉及的靶基因及参与的信号通路等方面进行综述。

关键词: miRNA, 按蚊, 疟原虫, 功能, 调控

Abstract:

miRNA is a type of single-stranded non-coding RNA with a length of 21-24 bases. miRNA may lead to mRNA degradation or translation inhibition by targeting the 3′-end untranslated region of mRNA, and plays an important role in the defense response of Anopheles against pathogen invasion among many other biological processes. This article reviews the possible functions, and target genes and signaling pathways involved of miRNAs, during Anopheles infection with Plasmodium.

Key words: miRNA, Anopheles, Plasmodium, Function, Regulation

中图分类号:

R382.31

朱凌倩, 冯欣宇, 胡薇, 李石柱. miRNA在疟原虫感染按蚊过程中的功能及作用[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(6): 742-748.

ZHU Ling-qian, FENG Xin-yu, HU Wei, LI Shi-zhu. Functions and roles of miRNA during the infection of Anopheles by Plasmodium[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(6): 742-748.

图/表 1

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miRNA	疟原虫感染后表达变化	靶基因	功能	蚊媒
miR-1174	下调^[12]	丝氨酸羟甲基转移酶^[17]	调节相关的肠道功能,包括血液摄取、体液排泄和糖吸收^[17]	冈比亚按蚊（Anopheles gambiae）^[12,17]
MiR-276		支链氨基酸转移酶（BCAT）^[21]	蚊子的繁殖周期和恶性疟原虫（Plasmodium falciparum）的发育^[21]	An. coluzzii^[21]
miR-305	上调^[14]	可能调控已知的抗疟原虫效应基因^[14]	恶性疟原虫（P. falciparum）的发育、肠微生物群的免疫力^[14]	冈比亚按蚊（An. gambiae）^[14]
miR-989	上调^[14]	潜在的候选基因:STAT蛋白抑制剂（PIAS）^[20]	中肠疟原虫发育的激动剂^[20]	冈比亚按蚊（An. gambiae）^[14]斯氏按蚊（An. stephensi）^[20]
miR-34	下调^[12]	抗氧化1（OXR1）^[20]胸腺素同工型2（Thymosin isoform 2）^[20]	疟原虫发育^[20]	冈比亚按蚊（An. gambiae）^[12]斯氏按蚊（An. stephensi）^[20]
miR-275	下调^[22]	amino acid/target of rapamycin(AA/TOR),20-羟基蜕皮激素^[23]	与疟原虫感染有关^[22]参与埃及伊蚊中的卵子发育,体液排泄,血液消化^[23]	嗜人按蚊（An. anthropophagus）^[22]

miRNA在疟原虫感染按蚊过程中的功能及作用

Functions and roles of miRNA during the infection of Anopheles by Plasmodium

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