华支睾吸虫miRNA在胆管癌发生发展中作用机制的研究进展

doi:10.12140/j.issn.1000-7423.2025.02.018

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (2): 269-273.doi: 10.12140/j.issn.1000-7423.2025.02.018

华支睾吸虫miRNA在胆管癌发生发展中作用机制的研究进展

武奥迅(), 钟籽丰, 徐安远, 潘筱雯, 易雪晴, 吴银娟, 李学荣^*()()

中山大学中山医学院，广东广州 510080

收稿日期:2024-06-06 修回日期:2024-08-04 出版日期:2025-04-30 发布日期:2025-02-26
通讯作者: * 李学荣（ORCID：0000-0002-5518-1617），男，博士，教授，从事病原生物感染与免疫的研究。E-mail： xuerong2@mail.sysu.edu.cn
作者简介:武奥迅，女，硕士研究生，从事病原生物感染与免疫的研究。E-mail：wuaox@mail2.sysu.edu.cn
基金资助:
国家重点研发计划(2021YFC2300800);国家重点研发计划(2021YFC2300801);广东省自然科学基金(2022A1515012560);广东省自然科学基金(2023A1515010955)

Research progress on the mechanism of Clonorchis sinensis miRNAs in the initiation and progression of cholangiocarcinoma

WU Aoxun(), ZHONG Zifeng, XU Anyuan, PAN Xiaowen, YI Xueqing, WU Yinjuan, LI Xuerong^*()()

Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China

Received:2024-06-06 Revised:2024-08-04 Online:2025-04-30 Published:2025-02-26
Contact: * E-mail： xuerong2@mail.sysu.edu.cn
Supported by:
National Key Research and Development Program of China(2021YFC2300800);National Key Research and Development Program of China(2021YFC2300801);Guangdong Natural Science Foundation(2022A1515012560);Guangdong Natural Science Foundation(2023A1515010955)

摘要/Abstract

摘要：

华支睾吸虫作为一种食源性寄生虫，其成虫寄生于宿主肝胆管内，可导致宿主肝胆管病变，甚至诱发胆管癌。华支睾吸虫于2009年被世界卫生组织国际癌症研究署列为Ⅰ类致癌物。微小RNA（miRNA）作为一类内源性的非编码RNA，在细胞内具有多种重要的调节作用。华支睾吸虫分泌的miRNA在肝胆管癌发生发展中扮演着重要的角色。本文综述了华支睾吸虫miRNA在肝胆管癌中的作用，以期为华支睾吸虫感染诱发的胆管癌防治提供新的策略。

关键词: 华支睾吸虫, miRNA, 胆管癌, 免疫调节

Abstract:

Clonorchis sinensis is a food-borne parasite. T he adult worms parasitize in the hepatic bile ducts of the host, which could cause pathological changes and induce cholangiocarcinoma. The International Agency for Research on Cancer of the World Health Organization classified C. sinensis as a Class Ⅰ carcinogen in 2009. As a class of endogenous non-coding RNA, micro RNA (miRNA) has a variety of important regulatory roles in cells. MiRNAs secreted by C. sinensis play a relatively important role in the initiation and progression of cholangiocarcinoma. This review summarized the roles of C. sinensis-derived miRNAs in cholangiocarcinoma, aiming to provide novel strategies for preventing and treating cholangiocarcinoma induced by C. sinensis infection.

Key words: Clonorchis sinensis, miRNA, Cholangiocarcinoma, Immune regulation

中图分类号:

R383.22

武奥迅, 钟籽丰, 徐安远, 潘筱雯, 易雪晴, 吴银娟, 李学荣. 华支睾吸虫miRNA在胆管癌发生发展中作用机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(2): 269-273.

WU Aoxun, ZHONG Zifeng, XU Anyuan, PAN Xiaowen, YI Xueqing, WU Yinjuan, LI Xuerong. Research progress on the mechanism of Clonorchis sinensis miRNAs in the initiation and progression of cholangiocarcinoma[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(2): 269-273.

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华支睾吸虫miRNA在胆管癌发生发展中作用机制的研究进展

Research progress on the mechanism of Clonorchis sinensis miRNAs in the initiation and progression of cholangiocarcinoma

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