自然杀伤T细胞在寄生虫感染免疫中作用的研究进展

doi:10.12140/j.issn.1000-7423.2020.04.014

中国寄生虫学与寄生虫病杂志 ›› 2020, Vol. 38 ›› Issue (4): 477-481.doi: 10.12140/j.issn.1000-7423.2020.04.014

自然杀伤T细胞在寄生虫感染免疫中作用的研究进展

刘毅¹^,²(), 蔡玉春², 陈韶红², 陈家旭²^,^*()

1 上海健康医学院医学技术学院,上海201318
2 中国疾病预防控制中心寄生虫病预防控制所,国家热带病研究中心,世界卫生组织热带病合作中心,科技部国家级热带病国际联合中心,卫生部寄生虫病原与媒介生物学重点实验室,上海200025

收稿日期:2019-10-22 出版日期:2020-08-30 发布日期:2020-09-09
通讯作者: 陈家旭
作者简介:刘毅（1981-）,男,讲师,博士研究生,从事寄生虫感染免疫研究。E-mail：liuy_52@sumhs.edu.cn
基金资助:
2019年上海健康医学院师资人才百人库项目(B1-0200-19-311143)

Advances in research on the roles of natural killer T cells in immune responses to parasitic infections

LIU Yi¹^,²(), CAI Yu-chun², CHEN Shao-hong², CHEN Jia-xu²^,^*()

1 Shanghai University of Medicine and Health Sciences, College of Medical Technology, Shanghai 201318, China
2 National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology, Ministry of Public Health, Shanghai 200025, China

Received:2019-10-22 Online:2020-08-30 Published:2020-09-09
Contact: CHEN Jia-xu
Supported by:
Hundred Talents Project of Shanghai University of Medicine & Health Sciences in 2019(B1-0200-19-311143)

摘要/Abstract

摘要：

自然杀伤T（NKT）细胞是一种同时具有T细胞与NK细胞表面标志的固有免疫细胞。NKT细胞活化后分泌的细胞因子具有影响适应性免疫的性质,是联系固有免疫和适应性免疫的桥梁之一,参与抗感染、肿瘤免疫、自身免疫病等过程。NKT细胞在寄生虫感染的免疫过程中也发挥着承接固有免疫与适应性免疫的重要作用,但目前对该领域的研究相对较少。本文主要对NKT细胞在利什曼原虫、疟原虫、锥虫和血吸虫感染免疫中作用的研究进展进行综述。

关键词: 寄生虫感染, 自然杀伤T细胞, 免疫

Abstract:

Natural killer T(NKT) cells are a type of innate immune cells that express both T cell and NK cell surface markers. The cytokines secreted by NKT cells upon activation possess some properties that affect the adaptive immunity, thus bridging innate and adaptive immunity and playing important roles in anti-infection processes, tumor immunity and autoimmune diseases. NKT cells also play an important role in bridging innate and adaptive immunity during immune responses to parasitic infections. However, little research has been conducted in this field. In this article, the roles of NKT cells in immune responses to Leishmania, Plasmodium, Trypanosoma and Schistosoma infections are reviewed.

Key words: Parasite infection, Natural killer T cells, Immunity

中图分类号:

刘毅, 蔡玉春, 陈韶红, 陈家旭. 自然杀伤T细胞在寄生虫感染免疫中作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(4): 477-481.

LIU Yi, CAI Yu-chun, CHEN Shao-hong, CHEN Jia-xu. Advances in research on the roles of natural killer T cells in immune responses to parasitic infections[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(4): 477-481.

参考文献 41

[1]	Farr AR, Wu WS, Choi B, et al. CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells[J]. Proc Natl Acad Sci USA, 2014,111(35):12841-12846.
[2]	Wang C, Liu X, Li ZY, et al. CD8(+)NKT-like cells regulate the immune response by killing antigen-bearing DCs[J]. Sci Rep, 2015,5:14124.
[3]	Kaszubowska L, Foerster J, Kwiatkowski P, et al. NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors[J]. Folia Histochem Cytobiol, 2018,56(4):231-240.
[4]	Holzapfel KL, Tyznik AJ, Kronenberg M, et al. Antigen-dependent versus-independent activation of invariant NKT cells during infection[J]. J Immunol, 2014,192(12):5490-5498.
[5]	Liao CM, Zimmer MI, Wang CR. The functions of type I and type II natural killer T cells in inflammatory bowel diseases[J]. Inflamm Bowel Dis, 2013,19(6):1330-1338.
[6]	Tormo N, del Remedio Guna M, Teresa Fraile M, et al. Immunity to parasites[J]. Curr Immunol Rev, 2011,7(1):25-43.
[7]	Yang JQ, Zhou YH, Singh RR. Effects of invariant NKT cells on parasite infections and hygiene hypojournal[J]. J Immunol Res, 2016: 2395645.
[8]	Smiley ST, Lanthier PA, Couper KN, et al. Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice[J]. J Immunol, 2005,174(12):7904-7911.
[9]	Ronet C, Darche S, Leite de Moraes M, et al. NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii[J]. J Immunol, 2005,175(2):899-908.
[10]	Lotter H, González-Roldán N, Lindner B, et al. Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess[J]. PLoS Pathog, 2009,5(5):e1000434.
[11]	Lotter H, Helk E, Bernin H, et al. Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells[J]. PLoS One, 2013,8(2):e55694.
[12]	Zamora-Chimal J, Hernández-Ruiz J, Becker I. NKT cells in leishmaniasis[J]. Immunobiology, 2017,222(4):641-646.
[13]	Belo R, Santarém N, Pereira C, et al. Leishmania infantum exoproducts inhibit human invariant NKT cell expansion and activation[J]. Front Immunol, 2017,8:710.
[14]	Zamora-Chimal J, Fernández-Figueroa EA, Ruiz-Remigio A, et al. NKT cell activation by Leishmania mexicana LPG: Description of a novel pathway[J]. Immunobiology, 2017,222(2):454-462.
[15]	Jafarzadeh A, Nemati M, Sharifi I, et al. Leishmania species-dependent functional duality of toll-like receptor 2[J]. IUBMB Life, 2019,71(11):1685-1700.
[16]	Kumari S, Jamal F, Shivam P, et al. Leishmania donovani skews the CD56(+) natural killer T cell response during human visceral leishmaniasis[J]. Cytokine, 2015,73(1):53-60.
[17]	Kumari S, Shivam P, Kumar S, et al. Leishmania donovani mediated higher expression of CCL4 induces differential accumulation of CD4⁺CD56⁺NKT and CD8⁺CD56⁺NKT cells at infection site[J]. Cytokine, 2018,110:306-315.
[18]	Kumari S, Shivam P, Hansa J, et al. CD8^dim but not CD8^bright cells positive to CD56 dominantly express KIR and are cytotoxic during visceral leishmaniasis[J]. Hum Immunol, 2018,79(8):616-620.
[19]	Ferraz R, Cunha CF, Pimentel MIF, et al. CD3⁺CD4^negCD8^neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a⁺ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis[J]. Parasit Vectors, 2017,10(1):219.
[20]	Cunha CF, Ferraz R, Pimentel MI, et al. Cytotoxic cell involvement in human cutaneous leishmaniasis: assessments in active disease, under therapy and after clinical cure[J]. Parasite Immunol, 2016,38(4):244-254.
[21]	Miller JL, Sack BK, Baldwin M, et al. Interferon-mediated innate immune responses against malaria parasite liver stages[J]. Cell Rep, 2014,7(2):436-447.
[22]	Ng SS, Engwerda CR. Innate lymphocytes and malaria-players or spectators?[J]. Trends Parasitol, 2019,35(2):154-162.
[23]	Chaves YO, da Costa AG, Pereira MLM, et al. Immune response pattern in recurrent Plasmodium vivax malaria[J]. Malar J, 2016,15:445.
[24]	Kijogi C, Kimura D, Bao LQ, et al. Modulation of immune responses by Plasmodium falciparum infection in asymptomatic children living in the endemic region of Mbita, western Kenya[J]. Parasitol Int, 2018,67(3):284-293.
[25]	Lehmann JS, Campo JJ, Cicéron M, et al. T cell subtypes and reciprocal inflammatory mediator expression differentiate P. falciparum memory recall responses in asymptomatic and symptomatic malaria patients in southeastern Haiti[J]. PLoS One, 2017,12(4):e0174718.
[26]	Mpina M, Maurice NJ, Yajima M, et al. Controlled human malaria infection leads to long-lasting changes in innate and innate-like lymphocyte populations[J]. J Immunol, 2017,199(1):107-118.
[27]	Coelho-Dos-Reis JG, Li XM, Tsuji M. Development of a novel mechanism-based glycolipid adjuvant for vaccination[J]. F1000 Res, 2018,7.
[28]	Li XM, Kawamura A, Andrews CD, et al. Colocalization of a CD1d-binding glycolipid with a radiation-attenuated sporozoite vaccine in lymph node-resident dendritic cells for a robust adjuvant effect[J]. J Immunol, 2015,195(6):2710-2721.
[29]	Li XM, Huang J, Kawamura A, et al. Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect[J]. Vaccine, 2017,35(24):3171-3177.
[30]	Li XM, Huang J, Kaneko I, et al. A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice[J]. Expert Rev Vaccines, 2017,16(1):73-80.
[31]	Coelho-Dos-Reis JG, Huang J, Tsao T, et al. Co-administration of α-GalCer analog and TLR4 agonist induces robust CD8(+) T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells[J]. Clin Immunol, 2016,168:6-15.
[32]	Filtjens J, Coltel N, Cencig S, et al. The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection[J]. Front Immunol, 2016,7:472.
[33]	Guilmot A, Carlier Y, Truyens C. Differential IFN-γ production by adult and neonatal blood CD56+ natural killer (NK) and NK-like-T cells in response to Trypanosoma cruzi and IL-15[J]. Parasite Immunol, 2014,36(1):43-52.
[34]	Colato RP, Braz?o V, Santello FH, et al. Ageing is not associated with an altered immune response during Trypanosoma cruzi infection[J]. Exp Gerontol, 2017,90:43-51.
[35]	Deleeuw V, Pham HTT, De Poorter I, et al. Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice[J]. Parasite Immunol, 2019,41(10):e12664.
[36]	Matos MN, Cazorla SI, Schulze K, et al. Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi[J]. PLoS Negl Trop Dis, 2017,11(2):e0005300.
[37]	Mallevaey T, Fontaine J, Breuilh L, et al. Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine schistosomiasis[J]. Infect Immun, 2007,75(5):2171-2180.
[38]	Li L, Xie HY, Wang M, et al. Characteristics of IL-9 induced by Schistosoma japonicum infection in C57BL/6 mouse liver[J]. Sci Rep, 2017,7(1):2343.
[39]	Cha HF, Qin WJ, Yang Q, et al. Differential pulmonic NK and NKT cell responses in Schistosoma japonicum-infected mice[J]. Parasitol Res, 2017,116(2):559-567.
[40]	Chen DH, Zhao Y, Feng YF, et al. Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL/6 mice[J]. Innate Immun, 2019,25(4):224-234.
[41]	Sun T, Li G, Chen MJ, et al. Change of the Vα24 NKT cells in peripheral blood of the patients with advanced schistosomiasis and its relation to the degree of hepatic fibrosis[J]. Chin J Parasitol Parasit Dis, 2014,32(5):348-351. (in Chinese)
[41]	( 孙婷, 李刚, 陈茂剑, 等. 晚期血吸虫病患者外周血Vα24自然杀伤T细胞的变化及其与肝纤维化程度的关系[J]. 中国寄生虫学与寄生虫病杂志, 2014,32(5):348-351.)

自然杀伤T细胞在寄生虫感染免疫中作用的研究进展

Advances in research on the roles of natural killer T cells in immune responses to parasitic infections

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