中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (4): 492-496.doi: 10.12140/j.issn.1000-7423.2023.04.016
收稿日期:
2023-05-12
修回日期:
2023-07-17
出版日期:
2023-08-30
发布日期:
2023-09-06
通讯作者:
*孙希萌,(1984-),男,博士,副教授,从事寄生虫感染免疫学研究。E-mail:作者简介:
张旭(2001-),男,本科生,参与寄生虫感染免疫学研究。E-mail:zhangxu@mail.ccmu.edu.cn
基金资助:
Received:
2023-05-12
Revised:
2023-07-17
Online:
2023-08-30
Published:
2023-09-06
Contact:
*E-mail:Supported by:
摘要:
旋毛虫感染可引起严重危害人类健康的人兽共患旋毛虫病。旋毛虫生活史的各个阶段均能影响宿主的免疫应答。免疫逃逸机制是一种常见的自然选择机制,是病原体在自然选择下对免疫系统的一种适应,可使病原体能解除或缓解人体的免疫应答,躲避来自免疫系统的攻击,确保其能继续生存、繁殖。本文综述了旋毛虫免疫逃逸机制在干扰固有免疫反应和适应性免疫反应等方面的研究进展。深入研究旋毛虫的免疫逃逸机制对旋毛虫病的防控、人体自身免疫性疾病和过敏性疾病的治疗有重要意义。
中图分类号:
张旭, 孙希萌. 旋毛虫感染免疫逃逸机制研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(4): 492-496.
ZHANG Xu, SUN Ximeng. Research progress on the immune evasion mechanism in Trichinella spiralis infection[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(4): 492-496.
[1] | Wang GY, Chen DD, Zheng XL, et al. Relationship between the infectivity of encysted larvae and the developmental stage of Trichinella spiralis[J]. Chin J Parasitol Parasit Dis, 2020, 38(6): 785-788. (in Chinese) |
(王国英, 陈丹丹, 郑学礼, 等. 旋毛虫成囊幼虫的感染性与其发育阶段的关系[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(6): 785-788.) | |
[2] | Wang GY, Li XH. Experimental observation of the development of Trichinella spiralis muscle larvae in mice[J]. Chin J Parasitol Parasit Dis, 2019, 37(2): 235-237. (in Chinese) |
(王国英, 李祥会. 旋毛虫肌幼虫在小鼠体内发育的实验观察[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(2): 235-237.) | |
[3] |
Else KJ. Have gastrointestinal nematodes outwitted the immune system?[J]. Parasite Immunol, 2005, 27(10/11): 407-415.
doi: 10.1111/pim.2005.27.issue-10-11 |
[4] | Su L, Wang H. Research progress on pathogen infection and its immune escape mechanism[J]. Biotechnol Commun, 2016, 27(4): 582-585. (in Chinese) |
(苏莉, 王慧. 病原体感染及其免疫逃逸机制研究进展[J]. 生物技术通讯, 2016, 27(4): 582-585.) | |
[5] | Liu BY, Wang C, Xing X, et al. Dynamic changes of dectin-2 expression on dendritic cells in mice infected with Trichinella spiralis[J]. Chin J Parasitol Parasit Dis, 2016, 34(2): 105-108. (in Chinese) |
(刘博宇, 王丞, 邢鑫, 等. 旋毛虫感染小鼠树突状细胞相关C型凝集素-2动态变化[J]. 中国寄生虫学与寄生虫病杂志, 2016, 34(2): 105-108.) | |
[6] | Wang J, Che XC. Experimental study on regulatory T cell acquisition and its immunosuppressive effect[J]. J Tianjin Med Univer, 2015, 21(5): 393-396. (in Chinese) |
(王凊, 车绪春. 调节性T细胞获得及其免疫抑制作用的实验研究[J]. 天津医科大学学报, 2015, 21(5): 393-396.) | |
[7] |
Näreaho A, Saari S, Meri S, et al. Complement membrane attack complex formation and infectivity of Trichinella spiralis and T. nativa in rats[J]. Vet Parasitol, 2009, 159(3/4): 263-267.
doi: 10.1016/j.vetpar.2008.10.037 |
[8] |
Gettins PG. Serpin structure, mechanism, and function[J]. Chem Rev, 2002, 102(12): 4751-4804.
doi: 10.1021/cr010170+ pmid: 12475206 |
[9] |
Molehin AJ, Gobert GN, McManus DP. Serine protease inhibitors of parasitic helminths[J]. Parasitology, 2012, 139(6): 681-695.
doi: 10.1017/S0031182011002435 pmid: 22310379 |
[10] |
van Gent D, Sharp P, Morgan K, et al. Serpins: structure, function and molecular evolution[J]. Int J Biochem Cell Biol, 2003, 35(11): 1536-1547.
doi: 10.1016/S1357-2725(03)00134-1 |
[11] |
Dzik JM. Molecules released by helminth parasites involved in host colonization[J]. Acta Biochim Pol, 2006, 53(1): 33-64.
pmid: 16410836 |
[12] |
Zhao X, Hao YW, Yang J, et al. Mapping of the complement C9 binding domain on Trichinella spiralis paramyosin[J]. Parasit Vectors, 2014, 7: 80.
doi: 10.1186/1756-3305-7-80 pmid: 24564979 |
[13] |
Zhang ZF, Yang J, Wei JF, et al. Trichinella spiralisparamyosin binds to C8 and C9 and protects the tissue-dwelling nematode from being attacked by host complement[J]. PLoS Negl Trop Dis, 2011, 5(7): e1225.
doi: 10.1371/journal.pntd.0001225 |
[14] |
Hao YW, Zhao X, Yang J, et al. Monoclonal antibody targeting complement C9 binding domain of Trichinella spiralis paramyosin impairs the viability of Trichinella infective larvae in the presence of complement[J]. Parasit Vectors, 2014, 7: 313.
doi: 10.1186/1756-3305-7-313 |
[15] |
Chen Y, Shao S, Huang JJ, et al. Therapeutic efficacy of a Trichinella spiralis paramyosin-derived peptide modified with a membrane-targeting signal in mice with antigen-induced arthritis[J]. Front Microbiol, 2020, 11: 608380.
doi: 10.3389/fmicb.2020.608380 |
[16] |
Sun R, Zhao X, Wang ZX, et al. Trichinella spiralis paramyosin binds human complement C1q and inhibits classical complement activation[J]. PLoS Negl Trop Dis, 2015, 9(12): e0004310.
doi: 10.1371/journal.pntd.0004310 |
[17] |
Zhao LM, Shao S, Chen Y, et al. Trichinella spiralis calreticulin binds human complement C1q as an immune evasion strategy[J]. Front Immunol, 2017, 8: 636.
doi: 10.3389/fimmu.2017.00636 |
[18] |
Gao X, Yang Y, Liu XL, et al. Extracellular vesicles from Trichinella spiralis: proteomic analysis and protective immunity[J]. PLoS Negl Trop Dis, 2022, 16(6): e0010528.
doi: 10.1371/journal.pntd.0010528 |
[19] |
Sun XK, Li Y, Naqvi MA, et al. Succinate coenzyme A ligase beta-like protein from Trichinella spiralis suppresses the immune functions of rat PBMCs in vitro and inhibits the secretions of interleukin-17 in vivo[J]. Vaccines, 2019, 7(4): 167.
doi: 10.3390/vaccines7040167 |
[20] | Wang XL, Li L, Zhang H, et al. Effect of exogenous nitric oxide on antioxidants from mice infected with Trichinella spiralis[J]. Chin J Schisto Control, 2017, 29(1): 48-52, 58. (in Chinese) |
(王小莉, 李亮, 张慧, 等. 外源性一氧化氮对旋毛虫感染小鼠抗氧化能力的影响[J]. 中国血吸虫病防治杂志, 2017, 29(1): 48-52, 58.) | |
[21] |
Du LL, Wei HY, Li LQ, et al. Regulation of recombinant Trichinella spiralis 53-kDa protein (rTsP53) on alternatively activated macrophages via STAT6 but not IL-4Rα in vitro[J]. Cell Immunol, 2014, 288(1/2): 1-7.
doi: 10.1016/j.cellimm.2014.01.010 |
[22] | Yu JL, Bai X, Liu GX, et al. Toxicity of serine ptotease of adult Trichinella spiralis on S774A.1 macrophages[J]. Prog Vet Med, 2011, 32(10): 5-9. (in Chinese) |
(于建立, 白雪, 刘国兴, 等. 旋毛虫成虫丝氨酸蛋白酶对S774A.1巨噬细胞的毒性作用[J]. 动物医学进展, 2011, 32(10): 5-9.) | |
[23] | Li TT. Functional study on three cysteine protease inhibitors of Trichinella spiralis and establishment of polymerase amplification detection method for recombinant enzyme[D]. Beijing: Chinese Academy of Agricultural Sciences, 2019. (in Chinese) |
(李婷婷. 旋毛虫三种半胱氨酸蛋白酶抑制因子的功能研究及重组酶聚合酶扩增检测方法的建立[D]. 北京: 中国农业科学院, 2019.) | |
[24] | Gao X, Yang Y, Liu L, et al. Isolation and small RNA identification of exosomes in the larval stage of Trichinella muscle[J]. J Chin Zoonoses, 2020, 36(04): 261-266. (in Chinese) |
(高欣, 杨勇, 刘蕾, 等. 旋毛虫肌幼虫期外泌体的分离和小RNA鉴定[J]. 中国人兽共患病学报, 2020, 36(4): 261-266.) | |
[25] | Liu L, Yang Y, Gao X, et al. Preliminary prevention effect of Trichinella spiralis extracellular vesicles on TNBS-induced experimental colitis in mice[J]. Prog Vet Med, 2020, 41(5): 67-73. (in Chinese) |
(刘蕾, 杨勇, 高欣, 等. 旋毛虫细胞外囊泡对TNBS诱导的小鼠实验性结肠炎的初步干预作用[J]. 动物医学进展, 2020, 41(5): 67-73.) | |
[26] |
Yang Y, Liu L, Liu XL, et al. Extracellular vesicles derived from Trichinella spiralis muscle larvae ameliorate TNBS-induced colitis in mice[J]. Front Immunol, 2020, 11: 1174.
doi: 10.3389/fimmu.2020.01174 |
[27] |
Han CX, Yu J, Zhang ZQ, et al. Immunomodulatory effects of Trichinella spiralis excretory-secretory antigens on macrophages[J]. Exp Parasitol, 2019, 196: 68-72.
doi: 10.1016/j.exppara.2018.10.001 |
[28] | Liu BY, Wang C, Xing X, et al. Dynamic changes of dectin-2 expression on dendritic cells in mice infected with Trichinella spiralis[J]. Chin J Parasitol Parasit Dis, 2016, 34(2): 105-108. (in Chinese) |
(刘博宇, 王丞, 邢鑫, 等. 旋毛虫感染小鼠树突状细胞相关C型凝集素-2动态变化[J]. 中国寄生虫学与寄生虫病杂志, 2016, 34(2): 105-108.) | |
[29] |
Jin XM, Yang Y, Liu XL, et al. Glutathione-S-transferase of Trichinella spiralis regulates maturation and function of dendritic cells[J]. Parasitology, 2019, 146(14): 1725-1732.
doi: 10.1017/S003118201900115X |
[30] |
Ilic N, Gruden-Movsesijan A, Cvetkovic J, et al. Trichinella spiralis excretory-secretory products induce tolerogenic properties in human dendritic cells via Toll-like receptors 2 and 4[J]. Front Immunol, 2018, 9: 11.
doi: 10.3389/fimmu.2018.00011 |
[31] |
Huang L, Gebreselassie NG, Gagliardo LF, et al. Eosinophil-derived IL-10 supports chronic nematode infection[J]. J Immunol, 2014, 193(8): 4178-4187.
doi: 10.4049/jimmunol.1400852 pmid: 25210122 |
[32] |
Kobpornchai P, Reamtong O, Phuphisut O, et al. Serine protease inhibitor derived from Trichinella spiralis (TsSERP) inhibits neutrophil elastase and impairs human neutrophil functions[J]. Front Cell Infect Microbiol, 2022, 12: 919835.
doi: 10.3389/fcimb.2022.919835 |
[33] |
Ishikawa N, Goyal PK, Mahida YR, et al. Early cytokine responses during intestinal parasitic infections[J]. Immunology, 1998, 93(2): 257-263.
doi: 10.1046/j.1365-2567.1998.00412.x pmid: 9616376 |
[34] |
Mosmann TR. Cytokine secretion patterns and cross-regulation of T cell subsets[J]. Immunol Res, 1991, 10(3/4): 183-188.
doi: 10.1007/BF02919690 |
[35] |
Bioreau P, Vayssier M, Fabien JF, et al. Characterization of eleven antigenic groups in Trichinella genus and identification of stage and species markers[J]. Parasitology, 1997, 115 (6): 641-651.
doi: 10.1017/S0031182097001716 |
[36] | Wu XP. Screening and identification of antigenic genes of Trichinella spiralis at different development stages[D]. Changchun: Jilin University, 2009. (in Chinese) |
(吴秀萍. 旋毛虫不同发育时期抗原基因的筛选与鉴定[D]. 长春: 吉林大学, 2009.) | |
[37] | Zhai CC. Clonal expression and diagnostic characteristics of antigen genes at different developmental stages of Trichinella[D]. Beijing: Chinese Center for Disease Control and Prevention, 2018. (in Chinese) |
(翟铖铖. 旋毛虫不同发育时期抗原基因的克隆表达与诊断特性研究[D]. 北京: 中国疾病预防控制中心, 2018.) | |
[38] |
Sun XM, Guo K, Hao CY, et al. Trichinella spiralis excretory-secretory products stimulate host regulatory T cell differentiation through activating dendritic cells[J]. Cells, 2019, 8(11): 1404.
doi: 10.3390/cells8111404 |
[39] |
Kobpornchai P, Tiffney EA, Adisakwattana P, et al. Trichinella spiralis cystatin, TsCstN, modulates STAT4/IL-12 to specifically suppress IFN-γ production[J]. Cell Immunol, 2021, 362: 104303.
doi: 10.1016/j.cellimm.2021.104303 |
[40] |
Xie J, Shi CW, Huang HB, et al. Induction of the IL-10-producing regulatory B cell phenotype following Trichinella spiralis infection[J]. Mol Immunol, 2021, 133: 86-94.
doi: 10.1016/j.molimm.2021.02.012 |
[41] | Zhou YL. Dynamic changes of CD4+ T cell subsets and related cytokines in Trichinella spiralis infection[D]. Bengbu: Bengbu Medical College, 2019. (in Chinese) |
(周亚兰. CD4+ T细胞亚群及相关细胞因子在旋毛虫感染中的动态变化特征研究[D]. 蚌埠: 蚌埠医学院, 2019.) | |
[42] | Kosanović M, Cvetković J, Gruden-Movsesijan A, et al. Trichinella spiralis muscle larvae release extracellular vesicles with immunomodulatory properties[J]. Parasite Immunol, 2019, 41(10): e12665. |
[43] |
Jin QW, Zhang NZ, Li WH, et al. Trichinella spiralisthioredoxin peroxidase 2 regulates protective Th2 immune response in mice by directly inducing alternatively activated macrophages[J]. Front Immunol, 2020, 11: 2015.
doi: 10.3389/fimmu.2020.02015 |
[44] | Li MQ, Guo K, Sun XM. Impacts of Trichinella spiralis infection on innate immune system[J]. Chin Trop Med, 2017, 17(9): 941-946. (in Chinese) |
(李梦琪, 郭凯, 孙希萌. 旋毛虫感染对宿主固有免疫系统的影响[J]. 中国热带医学, 2017, 17(9): 941-946.)
doi: 10.13604/j.cnki.46-1064/r.2017.09.24 |
|
[45] |
Guo K, Sun XM, Gu Y, et al. Trichinella spiralis paramyosin activates mouse bone marrow-derived dendritic cells and induces regulatory T cells[J]. Parasit Vectors, 2016, 9(1): 569.
doi: 10.1186/s13071-016-1857-y |
[46] |
Aranzamendi C, de Bruin A, Kuiper R, et al. Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection[J]. Clin Exp Allergy, 2013, 43(1): 103-115.
doi: 10.1111/cea.12042 pmid: 23278885 |
[47] |
Motomura Y, Wang H, Deng Y, et al. Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis[J]. Clin Exp Immunol, 2009, 155(1): 88-95.
doi: 10.1111/j.1365-2249.2008.03805.x pmid: 19016806 |
[48] |
Gao X, Yang Y, Liu XL, et al. Extracellular vesicles derived from Trichinella spiralis prevent colitis by inhibiting M1 macrophage polarization[J]. Acta Trop, 2021, 213: 105761.
doi: 10.1016/j.actatropica.2020.105761 |
[49] | Rzepecka J, Harnett W. Helminth infections and their impact on global public health[M]. Cham: Springer International Publishing, 2022: 607-640. |
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