关键词: 裂殖子侵入, 恶性疟原虫, 红细胞膜, 秋水仙碱, 酶处理, 抑制作用, 植物凝集素, 完全培养基, 神经氨酸酶, 膜骨架蛋白

Abstract: By treating chemically and enzymatically erythrocytic membrane to change its structure and properties, the recognition of merozoite to erythrocyte and the effect of erythrocyte skeleton protein on the invasion of P. falciparum (Fcc-l/HN) were studied. It was found that the invasion of merozoite into erythrocyte digested with trypsin was greatly decreased; merozoite invasion into the erythrocyte treated with neuraminidase or wheat germ agglutinin (WGA) was partially inhibited; erythrocytes treated with cross-linker diamide and depolymerizer colchicine, N-ethyl maleinimide (NEM) of skeleton protein had evident resistance to invasion; the invasion of merozoite into erythrocyte treated with 2.0mM of NEM was completely blocked.