Research progress in the role of profilin in parasitic infection and immunity

doi:10.12140/j.issn.1000-7423.2019.06.017

Abstract

Abstract:

Profilin is an actin-binding protein highly conserved in all eukaryotes. It regulates the polymerization and depolymerization of actin, therefore affecting parasite movement and invasion in the host and inducing specific immune responses during parasite infection. Here we reviewed the structure and function of profilin, its role during parasite infection and immune responses in the host and its potential as a vaccine candidate and adjuvant, in order to provide reference for the better prevention and treatment of parasitic diseases.

Key words: Profilin, Parasite, Infection and immunity, Vaccine

CLC Number:

Fei-yu QIN, Hai-tong SONG, Xin ZHANG, Yu-di LI, Fei YUAN, Cheng HE, Zhuan-zhuan LIU. Research progress in the role of profilin in parasitic infection and immunity[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019, 37(6): 709-712.

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