Progress on the intervention of inflammatory conditions by helminthes and their derived molecules

doi:10.12140/j.issn.1000-7423.2021.03.014

Abstract

Abstract:

Inflammation is a complex protective response to pathogen invasion or tissue damage. Inflammation-related diseases include cardiovascular diseases, diabetes, asthma, obesity, etc. In recent years, accumulating evidence has shown that helminthes and their derived molecules can effectively interfere with inflammatory diseases, which leads to the ‘worm therapy’ concept. As administering with live worms is challenged with serious ethical and safety concerns, current research is focusing on the screening and structural analysis of worm-derived anti-inflammatory molecules, and identification and verification of anti-inflammatory effects. This article reviews the latest advances in worm-derived anti-inflammatory active molecules and the mechanisms underlying their intervention of inflammatory diseases.

Key words: Helminth, Anti-inflammatory molecule, Inflammatory diseases, Immune regulation

CLC Number:

R383

CHEN Yu-ying, WANG Xiao-ting, DAI Yang, CAO Jun. Progress on the intervention of inflammatory conditions by helminthes and their derived molecules[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(3): 380-385.

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