CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2024, Vol. 42 ›› Issue (5): 648-652.doi: 10.12140/j.issn.1000-7423.2024.05.013

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Research advances on the effects of helminth infection on bile acid metabolism

ZHANG Ying(), WANG Yugui, SHI Zhiqi, WANG Shuai*()   

  1. State Key Laboratory for Animal Disease Control and Prevention/College of Veterinary Medicine, Lanzhou University/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China
  • Received:2024-06-04 Revised:2024-09-02 Online:2024-10-30 Published:2024-10-21
  • Contact: * E-mail: wangshuai@caas.cn
  • Supported by:
    National Key Research and Development Program of China(2022YFD1800200);Science and Technology Major Project of Gansu Province(22ZD6NA001)

Abstract:

Parasitic helminths are widely distributed globally and have a significant impact on animal husbandry and public health. Helminth infection can affect metabolic and immune processes in the host. The latest research shows that helminth infection significantly alters host bile acid metabolism, which in turn directly or indirectly affects the host’s health and immune homeostasis. This article reviews the advances in research on the effects of nematodes, tapeworms, and flukes on host bile acid metabolism to provide new research ideas for the diagnosis, treatment, and prevention of related diseases.

Key words: Helminth infection, Bile acids, Metabolism

CLC Number: