Abstract: Cellular immunity plays an important role in defense against diseases， such as pathogenic infection，autoimmunity and tumor. With the progress of molecular immunology， mechanisms of T cellular immunity， and the T cell epitopes and functional genomics， studies on the prediction based on data-drived for T cell epitopes has been highlighted， and could be one of the useful tools for application in vaccine development. This review summarizes theory and method-ology of prediction for helper T cell epitopes， and their application in vaccine development against parasites， and new research directions are also discussed.

Key words: Helper T cell, Epitope prediction, Vaccine, Parasite