Research progress on the interaction between host cell autophagy and apicomplexa protozoa infection

doi:10.12140/j.issn.1000-7423.2021.06.015

Abstract

Abstract:

Autophagy is a conserved lysosome-depenendant degradation system widely present in eukaryotes, and intracellular substances are transported to lysosomes for degradation through this mechanism, which plays an important role in cell survival under stress conditions of starvation and hypoxia. In addition, cells can also eliminate foreign pathogens such as parasites and viruses through the clearance action of autophagy. Apicomplexa protozoa are obligatory intracellular parasites, often zoonotic pathogens, posing considerable threats to social development and public health. In recent years, researches on the interaction between autophagy and apicomplexa protozoa mainly focused on Toxoplasma gondii and Plasmodium. In this paper, we reviewed the progress of research on the interaction between autophagy and important Apicomplexa protozoa infection.

Key words: Autophagy, Apicomplexan, Toxoplasma gondii, Plasmodium

CLC Number:

R531

LU Fei, ZHUO Xun-hui, LU Shao-hong. Research progress on the interaction between host cell autophagy and apicomplexa protozoa infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(6): 826-831.

Figures/Tables 2

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