Associations of natural killer cells and their receptors with liver fibrosis in schistosomiasis

Abstract

Abstract:

Schistosomiasis japonica is a widespread zoonotic parasitic disease. The parasite eggs can deposit in the host liver after infection, causing hepatic fibrosis, which further progresses into cirrhosis. Schistosomiasis severely impairs the life quality of patients and has become a major public health problem. Natural killer (NK) cells are important innate immune cells, which can respond to the target without prior sensitization. Hepatic stellate cells (HSCs) are the major source of myofibroblasts that cause liver fibrosis in schistosomiasis. Recent studies showed that the NK cells can alleviate hepatic fibrosis by killing HSCs. The development of hepatic fibrosis is closely related to the status of NK cell activation, while the latter depends on the expression of their inhibitory or activating surface receptors. In this paper, recent research advances on NK cells and their surface receptors are reviewed, which provides a perspective of studies on the roles of NK cells against schistosomiasis liver fibrosis.

Key words: Schistosomiasis, Natural killer cell, Receptor, Hepatic fibrosis, Hepatic stellate cell

CLC Number:

R532.21

Xiao-ling WANG, Yuan HU, Jian-ping CAO. Associations of natural killer cells and their receptors with liver fibrosis in schistosomiasis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(5): 504-509.

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