Effects of endoplasmic reticulum stress in parasite infection

Abstract

Abstract:

Endoplasmic reticulum stress (ERS) is a disorder of endoplasmic reticulum homeostasis caused by excessive secretion of proteins or protein misfolding under infection and other stressors.ERS triggers a series of signaling and transcriptional events, termed unfolded protein response (UPR).Although UPR can restore endoplasmic reticulum homeostasis by reducing protein translation, aiding protein folding and degrading misfolded protein, long-term, serious ERS causes apoptosis of stressed cells and local inflammation.During infection of parasites, ERS is induced in host cells, together with initiation of UPR.The parasites can use this reaction in various ways to promote its survival and pathogenicity, and to influence inflammation, oxidative stress, apoptosis and immune responses of host cells.This review summarizes research progress on the effects of ERS in parasite infection, in the aim to provide new clues and ideas for investigating the relationship between parasites and host, and the control of parasitic diseases.

Key words: Parasite infection, Endoplasmic reticulum stress, Protozoa, Helminth

CLC Number:

Qi-pei WEI, Yong-fen QI, Yan-rong YU. Effects of endoplasmic reticulum stress in parasite infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(6): 617-622.

Figures/Tables 1

References 31

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