The role of Th17/Treg imbalance in liver fibrosis in schistosomiasis

Abstract

Abstract:

Liver fibrosis in schistosomiasis is a serious pathological consequence from immune reactions to schistosome infection. The progression of liver fibrosis depends on the state of immune response. Recent studies have found that Th17 and Treg cells are two subsets of CD4⁺T cells. The Th17 cells are mainly involved in inflammatory responses, while the Treg cells mainly mediate downregulation of the responses. Under normal conditions, the differentiations of the two subsets are inhibited by each other, and they function oppositely. The balance between Th17 and Treg cells, as well as the balance between them, play an important role in the maintenance of homeostasis and are involved in inflammatory responses, tissue trauma, fibrosis and development of many diseases. This paper reviews the role of Th17/Treg cells and their imbalance in liver fibrosis in schistosomiasis.

Key words: Schistosomiasis, Hepatic fibrosis, Helper T cell 17, Regulatory T cell, Immunological balance

CLC Number:

R532.21

Yong-hua ZHOU, Ying-ying YANG, Xiao-lin FAN, Xue SAI. The role of Th17/Treg imbalance in liver fibrosis in schistosomiasis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(1): 89-93.

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