Research progress on the role of immune cells in liver fibrosis due to schistosomiasis

doi:10.12140/j.issn.1000-7423.2022.01.013

Abstract

Abstract:

Schistosomiasis is a widespread zoonotic parasitic disease. After infected, Schistosoma japonicum deposit eggs in the host liver, forming granulomatous, and consequently leading to liver fibrosis, and even cirrhosis in severe cases. Recent studies have reported that immune cells play critical roles in liver fibrosis. Helper T 17 cells, γδ T cells and dendritic cells may advance schistosomiasis liver fibrosis, while regulatory T cells and natural killer cells suppress the liver fibrosis, and B cells, macrophages and natural killer T cells may play dual roles. Here we reviewed the action mechanisms of different types of immune cells in liver fibrosis of schistosomiasis.

Key words: Schistosomiasis, Liver fibrosis, Immune cell, Cytokine

CLC Number:

R532.21

GAO Yuan, HU Yuan, CAO Jian-ping. Research progress on the role of immune cells in liver fibrosis due to schistosomiasis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(1): 88-93.

References 51

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