›› 2010, Vol. 28 ›› Issue (5): 12-381.

• 综述 • Previous Articles     Next Articles

Effect of toll-like receptors on helminth infection

YU Yan-rong 1 *,QI Yong-fen1,2   

  1. 1 Department of Medical Parasitology,School of Basic Medical Sciences,Peking University,Beijing 100191,China;2 Laboratory of Bioactive Molecule,School of Basic Medical Sciences,Peking University,Beijing 100191,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-10-30 Published:2010-11-09
  • Contact: YU Yan-rong

Abstract:

Toll-like receptors(TLRs) as a family of pattern-recognition receptors are vital for immune and inflammatory responses, and also play an important role in helminth infection. By regulating TLRs expression and function, helminth can alter host immune response, interfere with disease progression, and change the immune microenvironment of host. This review summarizes the biological characteristics of TLRs and recent advances of TLRs in immune modulation on helminth infection.

Key words: Toll-like receptor, Parasite, Helminth, Immune modulation