Abstract: Development of vaccine against schistosomiasis japonica has been incorporated into WHO/TDR and China′s main disease control research programs. In recent years，the research on the anti-schistosomiasis vaccine has made significant progress. With the development of proteomics and molecular biology technology, Anti-Schistosoma japonicum vaccine research has been developed to a stage of genetic engineering in our country and DNA vaccines have become the main direction. It reveals new ways to enhance the immunoprotection of Schistosoma japonicum vaccine through screening new candidate antgens， optimizing combination of the mixed/multivalent vaccines， or adjuvant addition.

Key words: Schistosoma japonicum, Vaccine, Immune, Advance