Abstract: 　Objective] To study the protective immunity against Schistosoma japonicum (Sj) cercariae challenge in mice immunized with FhGST or AsGST. [Methods] Three groups of Kunming mice were immunized three times with rSjGST, FhGST and AsGST, respectively. Then 30 cercariae of Schistosoma japonicum were given per mouse by abdominal skin inoculation. Six weeks later, all mice were killed to collect adult worms, liver, spleen and large intestine for worm count and egg count. [Results] The worm burden was reduced by 27 8%～36 4% in the three immune groups compared with the two control groups ( P <0 05). rSj26GST, FhGST and AsGST significantly decreased the number of eggs deposited in the tissues. [Conclusion]: FhGST and AsGST could induce protection against S japonicum cercariae infection.

Key words: GST, Schistosoma japonicum, Fasciola hepatica, Ascaris suum .